In this paper, we first define type-two degenerate poly-Changhee polynomials of the second kind by using modified degenerate polyexponential functions. We derive new identities and relations between type-two degenerate poly-Changhee polynomials of the second kind. Finally, we derive type-two degenerate unipoly-Changhee polynomials of the second kind and discuss some of their identities.</jats:p