In response to an increasing availability of statistically rich observational
data sets, the performance and applicability of traditional Atmospheric
Cherenkov Telescope analyses in the regime of systematically dominated
measurement uncertainties is examined. In particular, the effect of systematic
uncertainties affecting the relative normalisation of fiducial ON and
OFF-source sampling regions - often denoted as {\alpha} - is investigated using
combined source analysis as a representative example case. The traditional
summation of accumulated ON and OFF-source event counts is found to perform
sub-optimally in the studied contexts and requires careful calibration to
correct for unexpected and potentially misleading statistical behaviour. More
specifically, failure to recognise and correct for erroneous estimates of
{\alpha} is found to produce substantial overestimates of the combined
population significance which worsen with increasing target multiplicity. An
alternative joint likelihood technique is introduced, which is designed to
treat systematic uncertainties in a uniform and statistically robust manner.
This alternate method is shown to yield dramatically enhanced performance and
reliability with respect to the more traditional approach.Comment: 26 pages, 7 figure