Dusikate analogy ftalocyaninu jako fotosensitizery ve fotodynamicke terapii.

Abstract

The first measurements of the photodynamic activity made with azaphthalocyanines (AzaPc) substituted with diethylamine and 6-aminohexanoic acid have confirmed the prediction of the singlet oxygen production. In the beginning negative results from the in vitro tests on cells have been made account of a found increased ability of aggregation only. Later there was found that the singlet oxygen production is also negatively influenced by the chosen substitution. This may be the main reason for zero photodynamic activity of this AzaPc on cells; however, the aggregation takes place in this effect, too. Results from observations of heteroatom influence on the singlet oxygen production have brought some light into the above mentioned negative results on cells. There was found that AzaPc containing the alkylamino substitution on the periphery of the macrocycle are very low active in the singlet oxygen production. This activity is almost negligible in comparison with alkoxy or the most active alkylsulfonyl substitutions. The last mentioned peripheral modifications are the most suitable for the next research because of other advantageous properties (the longest red shift of the Q band among the studied heteroatoms and a sufficient stability during synthesis in comparison with alkoxy derivatives).Parts of the text in English.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi