Nektere imunologicke aspekty u diabetes mellitus 1. typu a pridruzenych autoimunit.

Abstract

Type 1 diabetes mellitus is an autoimmune disease and can be associated with other autoimmune endocrine disorders and also with autoimmune impairment of a non-endocrine tissue. In this work we studied specific antibodies against islet antigens - glutamic acid decarboxylase, protein thyrosine phosphatase IA-2?, against thyroid autoantigens - thyroid microsomal peroxidase, thyroglobulin, autoantigens of small bowel - endomysial autoantibodies, tissue transglutaminase autoantibodies, antibodies against gliadin in class IgA (AGA-IgA) and IgG (AGA-IgG), and adrenal cortex antibodies in a cohort of Type 1 diabetic patients. The autoantibodies were detected with special regard to the clinical status and with the aim to detect subclinically associated autoimmune thyroid disease, celiac disease and Addison's disease.Parts of the text in English.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi