Diagnosticke a patogeneticke aspekty autoprotilatek proti cytoplasmatickym antigenum neutrofilnich leukocytu.

Abstract

Antineutrophil cytoplasmic autoantibodies (ANCA) represent a heterogenous group of autoantibodies reacting with components of primary granules of polymorphonuclear leukocytes (PMN). Determination of the presence and type of ANCA became recently a part of routine diagnostic methods, which contribute to the laboratory diagnostics of systemic vasculitis, namely Wegener's granulomatosis. However, ANCA occur also in other diseases in which the significance is less clear. Several mechanisms by which ANCA may be involved in the pathogenesis of tissue damage were described. This dissertation thesis includes comments to the articles published already in Czech and international journals and contains full-text of articles prepared for publication. The unifying theme of these articles are antineutrophil cytoplasmic antibodies and vasculitis. Clinically oriented articles deal with diagnostic and therapeutic aspects of ANCA and associated diseases in childhood as well as in adulthood. Experimental works are concentrated on pathogenic mechanisms of ANCA action, namely to the influence of bactericidal mechanisms of PMN, the influence of apoptosis and the evaluation of cytokines and adhesion molecules in ANCA-associated diseases.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi