Objective of the workshop is to present and discuss some of the main issues relevant to drug use and adverse drug reactions in Italy. The first session is related to adverse drug reactions surveillance and the second session to the appropriateness of drug use and regulatory activities. Italian experiences on adverse drug reaction studies in emergency departments, in children and during vaccination campaigns are presented. At the end of the workshop the activities of the National Center for drug evaluation are illustratedConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome Istituto Superiore di Sanita' - Viale Regina Elena, 299, Rome / CNR - Consiglio Nazionale delle RichercheSIGLEITItal