Moznosti ovlivneni vyskytu febrilnich epizod a delky hospitalizace u neutropenickych nemocnych.

Abstract

Intensive therapy (with or without peripheral blood stem cell transplantation - PBSCT) of patients with haematologic malignancies is often very complicated. In this study the following problems were studied with the conclusions: 1. Application of granulocyte-colony stimulating factor (G-CSF) after autologous PBSCT: individual, patient-dependant criteria (e.g. the first day when absolute neutrophil count was below 0,5x109/1) could be optimal for starting the G-CSF application. 2. Causative factors for prolonged hospitalisation beyond the point of engraftment in patients after autologous PBSCT: in spite of rapid engraftment other complications, especially persisting non-haematologic toxicities and infections, remain important limitations for further reduction of the length of patient's hospitalisation. 3. Some aspects that can influence the incidence of febrile episodes and length of hospitalisation in neutropenic patients. A retrospective analysis of two types of antibacterial prophylaxis was performed in patients after allogeneic bone marrow transplantation with conclusions, that the addition of trimethoprim/sulphamethoxazole to fluoroquinolone appears to be inexpensive, non toxic, well-tolerated and effective preventive regimen able to decrease the incidence of G-sepsis. The practical impact of this adapted combination could come in the future. Guidelines for diagnosis and therapy of fever of undetermined origin are also presented.Available from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi