THE ROLE OF THE RETINOIC ACID IN THE PROCESS OF THE PROLIFERATION AND DIFFERENTIATION OF CELLS, LINE K562

Abstract

The object of investigation: the cultures of the man's cells. The purpose of the work: the investigation of effect of the retinoic acid on the cells of line K562. For the first tise, the capacity of the retinoic acid of facilitating the effect of the phorbol ether on the cells of line K562. Developed has been the model for the investigation of the interaction of the retinoid-activated system of delivery of a signal and the TPA-dependent system of delivery of a signal with the differentiation induction. A complex analysis of the proliferative activity, mRNA and transcription factors has been performed. The Data about the influence of the retinoic acid on the process of the TPA-induced differentiation of cells K562 will be used in the study process. The system of interaction of the two inductors of the differentiation (retinoic acid and phorbol ether) will allow tostudy the questions of determination and differentiation deeper. The field of application: studying the questions of proliferation, differentiation (ISC RAS, ICand G SD RAS)Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio