THE INFLUENCE OF THE HEREDITARY AND MEDIUM FACTORS ON THE METABOLIZING ACTIVITY OF THE SYSTEM OF CYTOCHROME P-450 AND THE FORMATION OF THE MEDICINAL MEANS EFFECTS

Abstract

Using the mice of the inbred lines, the genetic determination of the metabolizing activity of the cytochrome P-450 system has been confirmed, the homology of its oxidating phenotypes, established earlier for the human population, has been proved. It has been established, that inspecific supression of activity of the cytochrome P-450 system of the liver with the effect of the medium factors also depends on the phenotype of oxidation. The functional activity of the liver monooxigenases influences on the expressiveness of the anaphylactic shock. The possibility of reducing the dose of the promedicines of the fluorafur without loss of the antitumor activity due to the biotransformation induction has been shown. In the course of the screening investigations, the direction of the development of preparators-inductors of cytochromt P-450 has been determined at the modification of structures N-phenylpyrasol and adamanthane.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio