THE SYSTEMS OF IDENTIFICATION OF THE HOLOGIC REGIONS OF THE CHROMOSOMES: A COMPARATIVE CYTOGENETICS OF MAMMALS AND CHROMOSOME PATHOLOGIES OF THE MAN

Abstract

The new systems of the analysis of chromosomes on the high level of resolution in the cases, excluding the reception of the analogous results by other methods, have been developed. The base for mapping the genomes of the mink and fox has been created. The comparative analysis of the carnivorous animals and the man's chromosomes has been performed. The presence of the differences in the tempoes of the chromosome transformations of the mammals has been shown. The new method of receiving the region-specific DNA-microlibraries has been developed. The DNA-microlibraries, the part of which has been used for the analysis of the chromosome anomalies of the man, have been obtained. The developed methods and DNA-microlibraries are being used in the cytogenetic diagnostics of the chromosome pathologies of the man, in the analysis of the chromosome aberrations in the malignizied cells, at the comparative analysis of the chromosomes of the mammals can be recommended for the introduction in the work of the diagnostic laboratories of medical establishments.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio