Genetisches und zytogenetisches Monitoring chemisch-exponierter Beschaeftigtengruppen in der mikroelektronischen und chemischen Industrie. T. 1. Textband Schlussbericht

Abstract

The peripheral blood lymphocytes isolated from workers of different exposure situations - (1) plasma etching industry, (2) final chlorination of polyvinylchloride and (3) synthesis of monochlorodimethylether - and control subjects were examined for chromosomal mutations, sister chromatid exchanges, gene mutations and DNA-adducts. After careful consideration of the exposure environment in a microelectronic plant and the recognition of the critical exposure situation it was possible to introduce several improvements that led to measurable decrease in the number of chromosomal aberrations observed in lymphocytes. In the group of workers performing final chlorination of polyvinylchloride it could be shown that the DNA-adducts were the most sensitive parameter. In contrast, in the case of workers engaged in the synthesis of ethers chromosomal damage was determinated to be the most sensitive one. The results of the study have revealed the possibilities of improving the safety of the working place. Besides obtaining valuable information about the genotoxic and cancer risk of chemical exposure at the workingplace, information about the general health of the workers was obtained. (orig.)SIGLEAvailable from TIB Hannover: F96B1525+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman