Differential cellular kinetics and survival features of the main types of malignancy by patient age

Abstract

Incidence of neoplasm increases with age. However age-related differences in similar tumours are not well characterised and the biological reasons for the potential differences remain unknown. These are thought to include proliferation, apoptosis, cell survival (telomere maintenance/telomerase expression), chromosomal and genomic instability This increase in expectations of histological reporting has obviously impacted on the workload of pathologists. Consequently there is a move to delegate appropriate parts of this work to suitably trained and qualified senior scientists. This study aims to assess the differences between tumours of the young (70) and use the models derived from the morphological and biological assessments to add to the prognosis of tumours in the mid age group (50 - 70).EThOS - Electronic Theses Online ServiceGBUnited Kingdo