Pd-Catalysed [3 + 2]-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors <i>via in silico</i> analysis

Abstract

Pd-catalysed [3 + 2] cycloaddition reaction of VECs and nitrile oxides to access bis-heterocycles was developed. In silico-based studies suggested interaction with COX receptors that may be corroborated biologically in the future.</jats:p