The development of a novel strategy for the control of encrustation and blockage of Foley catheters

Abstract

Mutants of Pr. mirabilis resistant to triclosan were generated in the laboratory, they had not gained resistance to antibiotics, but they were able to form crystalline biofilms in the bladder model on catheters exposed to triclosan.  Clinical trials of this strategy should therefore monitor the urinary flora for signs of triclosan resistance. If this strategy can be transferred successfully from the laboratory to the clinic, it could produce a major improvement in the care of the many elderly and disabled patients enduring long-term bladder catheterisation.EThOS - Electronic Theses Online ServiceGBUnited Kingdo