Weight as predictors of clinical progression and treatment failure : results from the TREAT Asia pediatric HIV observational database

Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score, 23 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P <= 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings