Morrin, Aoife

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MicrostructuredConducting Polymers On-Chip1Dr. Aoife MorrinNational Centre for Sensor ResearchDublin City University75th Prague Meeting on Macromolecules 2011Outline Conducting polymers in chromatography Fabrication of conducting polymer monoliths on-chip µChip electrochemical cell design Electrochemistry on-chip Applications275th Prague Meeting on Macromolecules 2011Electroactive polymers as coatings on separation phases: Early work• Particulate packing: Ppy-coated silica particles• Chemical switching of PpystatesCaffeineTheophilineChriswanto & Wallace, J. Liq. Chrom. & RelTechnol., 19:2457 (1996)375th Prague Meeting on Macromolecules 201115 YEARS ON……TIME TO REVISIT!From particulates to monoliths in chromatographyPassive, inert structures comprised of rigid polymer rodsUV or thermally curable monomers, e.g., methacrylates, styrenes etc.475th Prague Meeting on Macromolecules 2011Conducting polymers as monoliths could provide:A new fabrication methodConducting stationary phasesDynamic separations (active)Do functional materials offer a viable alternative???ElectroactiveMonolith µChip (EMµ)575th Prague Meeting on Macromolecules 2011EMµ credentials Electrochemical growth of uniformly templated monolithic stationary phases Precise control over stationary phase fabrication enabling high reproducibility Micro-structuring of the monolithic stationary phase enabling: – Further decrease of the A-term in Van Deemter– Large flow through pores– Small skeleton size Precise electrochemical tuning of stationary phase before & during separation to affect:– Retention factors– Hydrophobicity/hydrophilicity– Pore size– Ionic capacity675th Prague Meeting on Macromolecules 2011Conducting polymer monoliths –fabrication on-chipTemplateDepositionDissolution of TemplateWorking Electrode IntegrationElectrochemical Polymer Growth7Channel Width: 110 micron75th Prague Meeting on Macromolecules 2011Dissolvable PS templatePS bead synthesisTwo Critical Factors: Appropriate cross-linkerconcentration to give uniformity andpermit dissolutionPS crystalin µfluidic channelSurfactant content of dispersions8vs.75th Prague Meeting on Macromolecules 2011Surfactant levels in PS dispersions –resulting PANI structures Increasing %w/v surfactant in dispersions -Order in resulting structures changes9Deionised Water 0.01 % w/v SDS 0.1 % w/v SDS 1 % w/v SDS75th Prague Meeting on Macromolecules 2011On-chip conducting polymer monolithPS TemplatePolyaniline Inverse Opal1075th Prague Meeting on Macromolecules 2011Micro-structured conducting polymers on-chip - unimodalPolyanilineOrder in 3-D           A new way for improving chip-to-chip reproducibility of monolithic stationary phases11Polypyrrole75th Prague Meeting on Macromolecules 2011Bimodal StructuresPS template comprising 3 micron & 300 nm beadsBimodal Ppy Monolith1275th Prague Meeting on Macromolecules 2011Composite structures for chip packingsPS template (3 µm beads)Ppy coated PS beads1375th Prague Meeting on Macromolecules 2011Dry and wetted states of inverse opalsDry State In Electrolyte Electrochemically grown micro-structured Ppy doped with DBS1475th Prague Meeting on Macromolecules 2011On-chip electrochemical cellGlass Base ChipPET lid with silver paste screen-printed cell electrodes(2)1575th Prague Meeting on Macromolecules 2011PANI electrochemistry on-chip50 mV s-116Correspondingcolour change on-chip1 M HClImproving chip design1775th Prague Meeting on Macromolecules 2011Target applications HPLC– Highly reproducible micro-structured polymer monolithic stationary phase for nanoLC, HPLC chip, and electrochromatography– EMLC: Precise tuning of stationary phase properties before & during separations (by application of a voltage) Lab-on-a-chip applications– Point of care diagnostics e.g., (multi-analyte) electrochemical sensing on-chip– Fluidic control1875th Prague Meeting on Macromolecules 2011Thanks! The organisers and audience at Prague Meeting on Macromolecules 2011   Dr. Blánaid White  Prof. Malcolm Smyth Prof. Gordon Wallace Prof. Tony Killard Dr. Damian Connolly Dr. Jeremy Galineau Brian Gorey Dr. Courtney Collins Orla Gaffney Dr. Fuqiang Nie Science Foundation Ireland & Enterprise Ireland1975th Prague Meeting on Macromolecules 2011REGISTRATION AND ABSTRACT SUBMISSION EXTENDED TO 30 JULYElectroactive PolymersPernigranilineHXEmeraldine BaseLeucoemeraldineAcidDoping`Emeraldine salt2175th Prague Meeting on Macromolecules 2011Surfactant Levels in PS Dispersions2275th Prague Meeting on Macromolecules 2011Packing conducting polymers on-chip? HPLC– Highly reproducible micro-structured polymer monolithic stationary phase for nanoLC, HPLC chip, and electrochromatography– EMLC: Precise tuning of stationary phase properties before & during separations (by application of a voltage) Lab-on-a-chip applications– Point of care diagnostics e.g., (multi-analyte) electrochemical sensing on-chip– Fluidic control ???? 2375th Prague Meeting on Macromolecules 2011Packing conducting polymer nanoparticles on chipPANI nanoparticles: 80 nmPack directly on-chip by capillary fill?2475th Prague Meeting on Macromolecules 2011

Micro-templated conducting polymers on-chip.

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Micro-templated conducting polymers on-chip.

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