Donnelly, Alan E.

Dowd, Kieran P.

Gray, Cleona

Harrison, Michael

McCarren, Andrew

Moyna, Niall M.

Murphy, Ronan

Sheridan, Sinead

Moyna, Niall

DCU Online Research Access Service

• RT & LT Far wall7.667 day Accelerometry Table. Participant characteristics, cIMT measurement, daily total ST, steps, and breaks in STValues are means  SDFigure 1.  Relation between total sitting time during waking hours and carotid intima media thicknessFigure 2.  Relation between daily steps and carotid intima media thickness  Figure 3.  Relation between breaks in sitting time and carotid intima media thickness Sinead Sheridan1, 2 Kieran P. Dowd3, Andrew McCarren4 Alan E. Donnelly5 Cleona Gray6, Michael Harrison7, Ronan P. Murphy2 and Niall M. Moyna2School of Public Health, The University of Hong Kong 1, School of Health and Human Performance, Dublin City University, Ireland 2, Faculty of Science and Health, Athlone Institute of Technology, Ireland 3,. School of Computing, Dublin City University, Ireland 4, Department of Physical Education and Sport Sciences, University of Limerick , Ireland 5, Mater Misericordiae University Hospital Dublin, Ireland 6,  Department of Sport and Exercise Science, Waterford Institute of Technology, Ireland 7 Institute of Technology , Waterford , Ireland.Relation between Sedentary Behavior, Physical Activity and Vascular Health in Male AdolescentsAbstractPresented at the 17th International Society of Behavioral Nutrition and Physical Activity (ISBNPA), Hong Kong. June 2018Purpose: Advanced vascular ageing (VA) has been found in children with cardiovascular disease risk factors. Limited studies have examined the association between sedentary behavior, physical activity and carotid intima media thickness (cIMT) in adolescents. The purpose of this study was to examine the associations of daily total sedentary time (ST), steps and breaks in ST with cIMT in apparently healthy male adolescents, and to determine if total ST, the number of breaks in ST or steps could identify adolescents with VA.Methods: A total of 54 apparently healthy male adolescents (mean ± SD: age 15.6 ± 0.7 yr.; BMI 23.0 ± 4.8) wore a tri-axial ActivPAL accelerometer for 7 consecutive days. Daily total ST during waking hours, the number of breaks in ST and total daily steps were calculated. High-resolution ultrasonography was used to measure left and right far wall intima media thickness (IMT) of the common carotid artery (CCA). Advanced VA was defined as having a mean far wall cIMT greater than or equal to the 25th percentile for race and sex matched healthy 45 year old 1. Associations between daily total ST during waking hours, steps and cIMT were examined using univariate correlation and regression analysis. Logistic regressions were conducted to determine if daily total ST, the number of breaks in ST or steps could identify adolescents with VA.Results: Daily total ST during waking hours was positively associated with cIMT (r= 0.37, p=0.006) and daily steps (r= -0.41, p=0.002) and the number of breaks in ST (r=-0.28, p =0.045) were inversely related to cIMT. After adjustment for the number of breaks in ST, total ST during waking hours and steps were significantly related to cIMT (β=0.02, p=0.032 and β= 8.89x10-6, p=0.018) when regressed using separate models against cIMT. The number of breaks in ST had significant odds ratio (OR=1.0745, p=0.035) when identifying adolescents with VA. Conclusion: The lower the number of breaks in ST, the higher the odds of advanced VA in apparently healthy male adolescents. Total ST and steps were significantly related to cIMT independent of the number of breaks in ST.ResultsConclusion Bibliography1. Howard, G., Sharrett, A.R., Heiss, G., Evans, G.W., Chambless, L.E., Riley, W.A., Burke, G.L. (1993). Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Invetsigators.Stroke, 24(9), 1297–13042. Le, J., Zhang, D., Menees, S., Chen, J., & Raghuveer, G. (2010). “Vascular age” is advanced in children withatherosclerosis-promoting risk factors. Circulation. Cardiovascular Imaging, 3(1), 8–14.The lower the number of breaks in ST, the higher the odds of advancedVA in apparently healthy male adolescents. Total ST and steps weresignificantly related to cIMT independent of the number of breaks in ST.Given that CVD begins in childhood, efforts to reduce overall ST, increasedaily steps and break up ST in children and adolescents is encouraged.IntroductionCarotid Intima Media thickness (cIMT) is a structural marker of cardiovascular disease (CVD). Vascular aging (VA) evaluates cIMT measurements against race and gender matched adult cIMT data and can stratify adolescents at risk of developing premature CVD. Advanced VA has been found in children with cardiovascular disease risk factors including obesity and familial dyslipidemia 2. Sedentary behavior is an independent risk factor for CVD. Limited studies have examined the association between sedentary behavior, physical activity and cIMT in adolescents. The purpose of this study was to examine the associations of daily total sedentary time (ST), steps and breaks in ST with cIMT in apparently healthy male adolescents, and to determine if total ST, the number of breaks in ST or steps could identify adolescents with VA.MethodscIMT measurement• Tri-axial ActivPAL• 7 days • ST during waking hours• Steps per day • Number of breaks in ST• B mode ultrasonography• Far wall IMT of left and right common carotid artery • Advanced VA =mean far wall cIMT ≥ or equal to the 25th percentile for race and sex matched healthy 45 year old 1r = -0.41, p=0.0020.20.30.40.50.60.70.83000 8000 13000 18000cIMT (mm)Steps per day r = -0.28, p=0.0450.20.30.40.50.60.70.820 40 60 80cIMT (mm)Breaks in Sitting Time (n)After adjustment for the number of breaks in ST, total ST during waking hours and steps were significantly related to cIMT (β=0.02, p=0.032 and β= 8.89x10-6, p=0.018) when regressed using separate models against cIMT. The number of breaks in ST had significant odds ratio (OR=1.0745, p=0.035) when identifying adolescents with VA.r =0.37, p=0.0060.20.30.40.50.60.70.85 6 7 8 9 10 11 12 13cIMT (mm)Sitting Time (h)

Relation between sedentary behavior, physical activity and vascular health in male adolescents

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Relation between sedentary behavior, physical activity and vascular health in male adolescents

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