Dégallier, Nicolas

Guerreiro, S.C.

Travassos da Rosa, A.P.A.

Travassos da Rosa, E.S.

Travassos da Rosa, J.F.S.

Vasconcelos, P.F.C.

Horizon / Pleins textes

REPORT fROM THE INSTITUTO EVANDRO CHAGAS, FSESP
Brazilian Ministery of Health, Belem, Brazil
OROPOUCHE VIRUS OUTBREAKS IN MARANHAO AND OOIAS STATES, BRAZIL
\
\
During the month of december 1987, the IEC was advised of an outbreak of
human febrile illness in Porto Franco, a .smal.I county located in south of
Maranhao state. A field team moved tu the area at the end january 1988 where
they collected blood from humans and, insects with the purpose of establishing
its virological and entomological characteristics. The population in the area was
-". said to be ar-ound 20,000 people, most of them living i.n Porto Franco, and the
<;
rest in nearby smaller settlements.
Human studies - Main symptoms observed were fever, headache, myalgias,
joints and back pains, photophobia, retrobulbar pain, nausea and dizziness.
Sudden onset was cormnonly ubserved and in many pati.ents there was a recurrence of
symptoms a few days or more than one week after the first episode 22 strains of
Oropouche(ORO) virus were obtained from the Int.r-acer-ebr-a l inoculation of the
blood of 75 febrile patients into 2-3 day-old infant mice. Of 197 people examined
125 had hemagglutinaUon - inhibiting(HI) antibodies to the agent while 106 of
them had 19M antibodies by MAC EUSA test. All age groups were infected and there
was no difference, in r-eIatIon to sex.
Entomological studies - 5,940 females of blood-sucking diptera were
collected and 5,936 were inoculated into baby mice as 137 pools for virus
isolation attempts. Over 60% of the insects belonged to the family
Ceratopogonidade, as shown in table 1. One single isolation of Oropouche virus
was obtained from a pool of 53 Culicoides paraensis.
In that opportunity, ten strains of ORO virus were also obtained from 45
samples of human blood received from Tocantinopolis, Goias state. By serology,
III and MAC ELISA, seven other sera were positive for the agent on study.
These are the first confirmed cases of ORO infection in Maranhao and
Goias states, Brazil.
(Pedro f. da Costa Vasconcelos, Jorge F.S. Travassos da Rosa, Sueli C. Guerreiro,
Nicolas Degallier, Elizabeth S. Travassos da Rosa and Amelia P.A. Travassos da
Rosa) •
28
Table 1 - Females of blood-sucking diptera collected in Porto Fr-anco , MA, Br-az i l .
" '
"
...
Species Collected· Inoculated Pools
CULICIDAE
Anophelinae
Anopheles (Anopheles) species
An. (N ssorh nchus) nuneztovari
An. (Nys. triannulatus
Culicinae
Aedini
Aedes [Och.ler-ot.at.us I scapularis
Psor'ophor'a (Grabhamia) cingulata + Ps , albipes
Ps. (Janthinosoma) ferox
Culicini
Culex species
Cx. (CarroJUa) species
Cx. (Culex) comiger
Cx • (Cux.) coronator
Cx , (Cux.) cor'onator + Cx , (Mel.) species
cs, (Cux.) dedarator'
Cx , (Cux , ) quinquefasdatus
Mansonijni
~. [Rhy , ] species + Ma. (tttan.) titillans
Sabethini
Limatus s ·'des
Sabethes Sabethoides) glaucodaemon
Wyeomyia species
Uranotaeniini
Uranotaenia species
CERATOPOGONIDAE
Culicoides (Oecacta) paraensis
Ceratopogonidae species Nr 1
Ceratopogonidae species Nr 2
SIMULIIDAE
Simulium species
GRAND TOTAL
1
20
7
7
12
1
9
6
2.253
3.624
1
1
3.626
61
5.940
o
20
7
1
6
4
15
1
51
6
4
132
1.970
7
12
1
8
6
2.251
3.624
o
o
3.624
61
5.936
o
I
1
1
I
1
..
,)
79
1
1
1
1
97
39
o
o
39
1
137
'lw~I////#a
June, 1989
TABLE OF CONTENTS
Page
Editor's Comments
Purpose of Arbovirus Information Exchange
Guidelines for submitting reports
Letter from W. C. Reeves
A suggested experiment (PA Nuttall, LD Jones, CR Davies)
DENGUE
i
li
li
lii
1
Monoclonal antibodies which recognize dengue virus complex (C Hermida,
CE Sosa, Vazquez, M Gonzalez, R Marcet, M Pupo, MG Guzman) 2
Retrospective seroepidemiological survey to dengue virus in 4
"Guantanamo Municipality". Preliminary results. (M Soler, MG Guzman,
G Kouri, L Morier, J Bravo, C Garbey)
Dengue hemorrhagic fever/dengue shock syndrome in infants, Cuba 1981. 8
(MG Guzman, G Kouri, M Valdez, E Martinez, M Soler)
(Continued on
next page)
IMPORTANT NOTICE: This Exchange is ~sued for the sole purpose of timely
exchange of information among people tudying all aspects of arboviruses. It
contains reports, summaries, observa ions, and comments submitted voluntarily
by qualified agencies and investigators. The appearance of any information,
d~ta, orinions, or views in this Exchange does not constitute formal
publLca r Lon and should not be e i ther referred to in "Reference" sections of
manuscripts or included in lists of publications; it is not a "peer reviewed"
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be authorized directly by the agency or person submitting the text.


Report from the Instituto Evandro Chagas, FSEP, Brazilian ministery of health, Belem, Brazil : Oropouche virus outbreaks in Maranhao and Goias states, Brazil

Report from the Instituto Evandro Chagas, FSEP, Brazilian ministery of health, Belem, Brazil : Oropouche virus outbreaks in Maranhao and Goias states, Brazil

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