Schistosoma bovis : vaccine effects of a recombinant homologous glutathione S-transferase in sheep

Abstract

The economic importance of the trematode #Schistosoma bovis in African livestock has justified the development of a specific vaccine. Administered preventively to sheep, rSb28GST - the only molecule cloned from #S. bovis which has demonstrated vaccine potentialities in goats and cattle - reduced the mean worm burden in vaccinated animals and improved their health status compared with that of non-vaccinated controls. As in goats, but not in bovines, the fecundity of the settled worm pairs was not modified. Therefore, rSb28GST can be proposed as a universal tool for the prevention of clinical disorders engendered by the main schistosome species affecting domestic ruminants in the African continent. (Résumé d'auteur