Метою статті є дослідження інституційної системи державної підтримки інвестиційних процесів у харчовій промисловості України з метою виявлення основних її складових та ролі кожного із них

Adrien Belem (3587630)

Domonbabele Hien (3240294)

Hermann Pooda (3587627)

Issa Sidibé (323662)

Jean-Baptiste Rayaisse (294177)

Karine Mouline (424330)

Philippe Solano (211311)

Roch Dabiré (133989)

Serge Yerbanga (3240300)

Thierry Lefèvre (63585)

Zakaria Bengaly (299044)

PubMed

Background: The success of current control tools in combatting malaria vectors is well established. However, sustained residual transmission of Plasmodium parasites persists. Mass drug administration (MDA) to humans of the endectocide ivermectin for vector control is receiving increasing attention. However, vectors feeding upon animals escape this promising approach. Zoophagy of mosquitoes sustains both the vector population and endemic population of vector-borne pathogens. Therefore, only a strategy that will combine ivermectin MDAs targeted at humans and their peridomestic animals could be successful at controlling residual malaria transmission. Methods: Burkinabe cattle have been treated with injectable therapeutic dose of ivermectin (0.2 mg/kg of body weight) to render blood meals toxic to field representative populations of Anopheles coluzzii carrying the kdr mutation. Direct skin-feeding assays were performed from 2 to 28 days after injection (DAI) and mosquitoes were followed for their survival, ability to become gravid and fecundity. Membrane feeding assays were further performed to test if an ivermectin blood meal taken at 28 DAI impacts gametocyte establishment and development in females fed with infectious blood. Results: The mosquitocidal effect of ivermectin is complete for 2 weeks after injection, whether 12 days cumulative mortalities were of 75 and 45 % the third and fourth weeks, respectively. The third week, a second ivermectin blood meal at sub-lethal concentrations further increased mortality to 100 %. Sub-lethal concentrations of ivermectin also significantly decreased egg production by surviving females, increasing further the detrimental effect of the drug on vector densities. Although females fitness was impaired by sub-lethal ivermectin blood meals, these did not diminish nor increase their susceptibility to infection. Conclusion: This study demonstrates the potential of integrated MDA of ivermectin to both human and peridomestic cattle to target vector reservoirs of residual malaria transmission. Such integration lies in 'One-Health' efforts being implemented around the globe, and would be especially relevant in rural communities in Africa where humans are also at risk of common zoonotic diseases

Pooda, H. S.

Rayaisse, J. B.

Hien, D. F. D.

Lefèvre, T.

Yerbanga, S. R.

Bengaly, Z.

Dabire, R. K.

Belem, A. M. G.

Sidibe, I.

Solano, Philippe

Mouline, Karine

Horizon / Pleins textes

Administration of ivermectin to peridomestic cattle : a promising approach to target the residual transmission of human malaria

Pooda, Hermann

Rayaisse, Jean-Baptiste

Hien, Domonbabele François de Sale

Lefèvre, Thierry

Yerbanga, Serge

Bengaly, Zakaria

Dabiré, Roch

Belem, Adrien

Sidibe, Issa

Archive Ouverte en Sciences de l'Information et de la Communication

Administration of ivermectin to peridomestic cattle: a promising approach to target the residual transmission of human malaria

Name not available

Additional file 3. Analysis of the effects of ivermectin treatment, the day after injection (DAI), the number of blood meals, and their interaction on female An. coluzzii’s survival using the Cox Proportional Hazards model

FigShare

MOESM3 of Administration of ivermectin to peridomestic cattle: a promising approach to target the residual transmission of human malaria

Hermann S. Pooda

Jean-Baptiste Rayaisse

Domonbabele François de Sale Hien

Thierry Lefèvre

Serge R. Yerbanga

Zakaria Bengaly

Roch K. Dabiré

Adrien M. G. Belem

Issa Sidibé

Philippe Solano

Karine Mouline

Crossref

Malaria Journal

Майборода, О.В.

Наукова електронна бібліотека періодичних видань НАН України (Vernadsky National Library of Ukraine)

Iнституційна система державної підтримки інвестиційних процесів у харчовій промисловості

Springer - Publisher Connector

International audienceBackground: The success of current control tools in combatting malaria vectors is well established. However, sustained residual transmission of Plasmodium parasites persists. Mass drug administration (MDA) to humans of the endectocide ivermectin for vector control is receiving increasing attention. However, vectors feeding upon animals escape this promising approach. Zoophagy of mosquitoes sustains both the vector population and endemic population of vector-borne pathogens. Therefore, only a strategy that will combine ivermectin MDAs targeted at humans and their peridomestic animals could be successful at controlling residual malaria transmission. Methods: Burkinabé cattle have been treated with injectable therapeutic dose of ivermectin (0.2 mg/kg of body weight) to render blood meals toxic to field representative populations of Anopheles coluzzii carrying the kdr mutation. Direct skin-feeding assays were performed from 2 to 28 days after injection (DAI) and mosquitoes were followed for their survival, ability to become gravid and fecundity. Membrane feeding assays were further performed to test if an ivermectin blood meal taken at 28 DAI impacts gametocyte establishment and development in females fed with infectious blood. Results: The mosquitocidal effect of ivermectin is complete for 2 weeks after injection, whether 12 days cumulative mortalities were of 75 and 45 % the third and fourth weeks, respectively. The third week, a second ivermectin blood meal at sub-lethal concentrations further increased mortality to 100 %. Sub-lethal concentrations of ivermectin also significantly decreased egg production by surviving females, increasing further the detrimental effect of the drug on vector densities. Although females fitness was impaired by sub-lethal ivermectin blood meals, these did not diminish nor increase their susceptibility to infection. Conclusion: This study demonstrates the potential of integrated MDA of ivermectin to both human and peridomes-tic cattle to target vector reservoirs of residual malaria transmission. Such integration lies in 'One-Health' efforts being implemented around the globe, and would be especially relevant in rural communities in Africa where humans are also at risk of common zoonotic diseases

HAL Descartes

https://figshare.com/articles/MOESM3_of_Administration_of_ivermectin_to_peridomestic_cattle_a_promising_approach_to_target_the_residual_transmission_of_human_malaria/4475114

Iнституційна система державної підтримки інвестиційних процесів у харчовій промисловості

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