In this article Marusya Churay*s (a character famous in story and song) life history is researched. On the basis of real events and historical facts the author tells about people who were related to the life of this personality

Altelaar, A F Maarten

Biboy, Jacob

Breukink, Eefjan

Colavin, Alexandre

Damen, Mirjam J

Den Blaauwen, Tanneke

Egan, Alexander J F

Gray, Andrew N

Gross, Carol A

Huang, Kerwyn Casey

Koumoutsi, Alexandra

Simorre, Jean-Pierre

Typas, Athanasios

Van't Veer, Inge L

Verheul, Jolanda

Vollmer, Waldemar

PubMed

To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope machines facilitating septal PG synthesis (PBP1B-LpoB complex) and OM constriction (Tol system) are physically and functionally coordinated via YbgF, renamed CpoB (Coordinator of PG synthesis and OM constriction, associated with PBP1B). CpoB localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction, interacts with both complexes, and regulates PBP1B activity in response to Tol energy state. This coordination links PG synthesis with OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modulating PBP1B cross-linking activity. Coordination of the PBP1B and Tol machines by CpoB contributes to effective PBP1B function in vivo and maintenance of cell envelope integrity during division

Gray, A.N.

Egan, A.J.F.

van 't Veer, I.L.

Verheul, J.

Colavin, A.

Koumoutsi, A.

Biboy, J.

Altelaar, A.F.M.

Damen, M.J.

Huang, K.C.

Simorre, J.P.

Breukink, E.

den Blaauwen, T.

Typas, A.

Gross, C.A.

Vollmer, W.

International Migration, Integration and Social Cohesion online publications

English

Coordination of peptidoglycan synthesis and outer membrane constriction during <i>Escherichia coli</i> cell division

UvA-DARE

NARCIS 

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

International audienceTo maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope machines facilitating septal PG synthesis (PBP1B-LpoB complex) and OM constriction (Tol system) are physically and functionally coordinated via YbgF, renamed CpoB (Coordinator of PG synthesis and OM constriction, associated with PBP1B). CpoB localizes to the septum concurrent with PBP1B-LpoB and Tol at the onset of constriction, interacts with both complexes, and regulates PBP1B activity in response to Tol energy state. This coordination links PG synthesis with OM invagination and imparts a unique mode of bifunctional PG synthase regulation by selectively modulating PBP1B cross-linking activity. Coordination of the PBP1B and Tol machines by CpoB contributes to effective PBP1B function in vivo and maintenance of cell envelope integrity during division

Van'T Veer, Inge L

Altelaar, a F Maarten

den Blaauwen, Tanneke

Hal - Université Grenoble Alpes

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division.

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