Рассмотрены особенности промышленности моноотраслевых городов Донецкой области. Предлагаются мероприятия по решению проблем их социально-экономического развития.Розглянуто особливості промисловості моногалузевих міст Донецької області. Пропонуються заходи щодо вирішення проблем їх соціально-економічного розвитку.The paper describes the features of the industry in mono-branch cities of Donetsk region. The measures are offered to solve the problems concerning their socio-economic development

Beijnen, Jos H

Dubbelman, Anne-Charlotte

Gupta, Anubha

Huitema, Alwin D R

Mergui-Roelvink, Marja

Nijenhuis, Cynthia

Rosing, Hilde

Schellens, Jan H M

Shumaker, Robert

Thompson, Gary

Verbel, David

Lenvatinib is an orally available multi-targeted tyrosine kinase inhibitor with anti-angiogenic and antitumor activity. To get more insight into the disposition of lenvatinib, a mass balance study was performed in patients with advanced solid tumors. A single oral 24 mg (100 μCi) dose of (14)C-lenvatinib was administered to six patients, followed by collection of blood, plasma, urine and feces for 7 to 10 days. The collected material was analyzed for total radioactivity, unchanged lenvatinib and selected metabolites. The safety and antitumor effect of a daily oral dose of 24 mg non-labeled lenvatinib were assessed in the extension phase of the study. Peak plasma concentrations of lenvatinib and total radioactivity were reached 1.6 and 1.4 h after administration, respectively, and their terminal phase half-lifes were 34.5 and 17.8 h, respectively. Unchanged lenvatinib systemic exposure accounted for 60 % of the total radioactivity in plasma. Peak concentrations of the analyzed metabolite were over 700-fold lower than the peak plasma concentration of lenvatinib. Ten days after the initial dose, the geometric mean (± CV) recovery of administered dose was 89 % ±10 %, with 64 % ±11 % recovered in feces and 25 % ±18 % in urine. Unchanged lenvatinib in urine and feces accounted for 2.5 % ±68 % of the administered dose, indicating a major role of metabolism in the elimination of lenvatinib. In conclusion, lenvatinib is rapidly absorbed and extensively metabolized, with subsequent excretion in urine and, more predominantly, in feces. Additionally, lenvatinib showed acceptable safety and preliminary antitumor activity

Utrecht University Repository

Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas

Кузьменко, Л.М.

Солдак, М.А.

Наукова електронна бібліотека періодичних видань НАН України (Vernadsky National Library of Ukraine)

Особенности промышленного развития монофункциональных городов Донецкой области

Sub Clinical Pharmacology

Pharmacoepidemiology and Clinical Pharmacology

NARCIS 

http://dspace.nbuv.gov.ua/help/2015_Statistic.pdf

Особенности промышленного развития монофункциональных городов Донецкой области

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Utrecht University Repository

Наукова електронна бібліотека періодичних видань НАН України (Vernadsky National Library of Ukraine)

NARCIS