Atmospheric carbon dioxide concentrations and climate are regulated on geological timescales by the balance between
carboninput fromvolcanicandmetamorphicoutgassingandits removalbyweathering feedbacks; these feedbacks involve
the erosion of silicate rocks and organic-carbon-bearing rocks. The integrated effect of these processes is reflected in the
calcium carbonate compensation depth, which is the oceanic depth at which calcium carbonate is dissolved. Here we
present a carbonate accumulation record that covers the past 53million years froma depth transect in the equatorial Pacific
Ocean. The carbonate compensation depth tracks long-termocean cooling, deepening from3.0–3.5 kilometres during the
early Cenozoic (approximately 55million years ago) to 4.6 kilometres at present, consistent with an overall Cenozoic
increase in weathering. We find large superimposed fluctuations in carbonate compensation depth during the middle
and late Eocene. Using Earth system models, we identify changes in weathering and the mode of organic-carbon
delivery as two key processes to explain these large-scale Eocene fluctuations of the carbonate compensation depth