ASANO, MOTOKAZU

KITAMURA, OSAMU

KOGIRE, MASAFUMI

NODA, HIDEKI

YAMADA, TOSHIHIKO

YOSHIDA, AKIKAZU

Kyoto University Research Information Repository

Title Carcinoma of the Cystic Duct : A Case ReportAuthor(s)KOGIRE, MASAFUMI; KITAMURA, OSAMU; YAMADA,TOSHIHIKO; NODA, HIDEKI; ASANO, MOTOKAZU;YOSHIDA, AKIKAZUCitation日本外科宝函 (1985), 54(6): 508-513Issue Date1985-11-01URL http://hdl.handle.net/2433/208722RightType Departmental Bulletin PaperTextversionpublisherKyoto UniversityArch Jpn Chir 54(6), 508～513, Nov. 1985 症例Carcinoma of the Cystic Duct: A Case Report :'llASAFUMI KoGIRE司 0SAMUKITAMURA司TOSHIHIKOV AMADA、HIDEKINODA、スlOTOKAZl’AsA>;Oand AKIKAZU VoちHIDAThe llcpartment of Surgery. the :¥ledical Center for Adult ])iseases, Shiga Received for Publication, July 3, 1985. Carcinoma of the cystic duct is extremely rare. According to F ARRAR2>, the following criteria must be satisfied for the diagnosis of primary carcinoma of the cystic duct: (1) the growth must be restricted to the cystic duct; (2) there must be no neoplastic process in the gallbladder, hepatic, or common bile ducts; (3) a histological examination of the growth must confirm the presence of carcinoma 何 ls. In 1978, MANABE and Sucrn3> reviewed only 21 cases in the literature that met FARRAR’s criteria, including their own case. Herein, we present an additio-Fig. I. A lκlominal CT scan sho"' an enlarged gal!Gladdcr、ithnの引idencじ1;i込 galstone.Key word汚： Carcinomaof the cystic duct, I! ydrops of the galしladder.索引語．胆袋行悔，胆袋~.kH重．Present address: The First Department of Surgery, Faculty of :¥lcdicine, Kyけtol1ni、円引t~ヘト日kyo ku、Kyotり・606, Japan. CARCI:¥O:¥IA ()F THE CYSTIC DlTT 509 nal case of primary carcinoma of the cystic duct, which was discovered accidentally during t、holecystectomy.Case Report A 70-year-old male was admitted to the Medical Center for Adult Di川、出札 Shiga,Japan, complaining of persistent right upper abdominal discomfort, which had be広unabout two years before. There wa~ no history of fever, jaundice, or abdominal pain. Physical examination revealed ,1 smooth, nontender mass of 7×5 cm in the right upper quadrant of the abdomen. Hematological and biochemical findings were within normal limits, except for a slight elevation of total bilirubin 1.44 mg/dl (normal range 0.10 1.00). An upper gastrointestinal X-ray series showed no abnormalities. Drip infusion cholangiography (DIC) disclosed nonvisualization of the gallbladder. Computed tomography (CT) and ultrasonography showed an enlarged gallbladder, with no evidence of a gallstone (Fig. 1). However, endoscopic Fig. 2. 町一Endoscopic retrograde cholangiopancreatography demonstrates a iaint tiling de-fet, presumably at the entry site of the qぉti<duct (arcl¥ I. The cy叫icduct and 宮allムdderare 0not opac恥 d.Dilatation 。fthe common bile duct and main pan-creatic duct is also noted. 510 日外宝第54巻第6号（昭和60年11月）retrograde cholangiopancreatography (ERCP) demonstrated a faint filling defect司 presumablyat the entry site of the cystic duct. The cystic duct and gallbladder were not opacified (Fig. 2). Hydrops of the gallbladder due to a stone impacted in the cystic duct was strongly suspected. At laparotomy, a firm nodule measuring 1.8×1.3×0.6 cm was found in the cystic duct near its entrance into the common bile duct (Fig. 3). The gallbladder was tense and distended司containing "white bile". However, there were no stones. A frozen section of the nodule re-vealed an adenocarcinoma. The gallbladder司cysticduct and a segment of the common bile duct were resected with removal of the regional lymph nodes, and a Roux-en-Y hepaticojejunostomy was performed. エIicroscopicexamination showed a moderately differentiated adenocarcinoma infiltrating to the subserosa of the cystic duct (Fig. 4). There was no evidence of malignancy in the gall-bladder, resected segment of the common bile duct, or the regional lymph nodes. Mild chronic inflammation was found in the gallbladder. The patient had an uneventful recovery、andwas discharged on the thirtieth postoperative day. He has remained well for twelve months since his operation, with no evidence of recurrence. Jγ♂－ 2周膨務夜 、＇.－ .,,, Fig. 3. l｛~sected :,pecimビnopened to show adcnocarcinoma of the t:y>tic duct (arrow). ぐ.－＼ RCl'\•Y\L-\ OF THE CY、~：·－ Drr""T Discussion Cases of primaηr carcinoma of the cァsticduct ,ire rn re IアI叩けII山I.p.1 rtly l 1，、川l>t、，，，‘it、lt1¥ incidence and partly because of the di伍cultyin di汎int'u1,;hin己itfrom ,-.ir川lh1¥l,l川 tht'g.tl-bladder, hepatic duct, or common bile duct in advanced r‘1,;c,; In addition 1, th＜、 ：1川、h Iγ、i. 1 ed by :'.fAXABE and St・c1EaJ in 1978‘only 3 more f品川、 th川 1山、tF¥RR、R.、じritni‘lh;t¥'l、het'nsubsequently reported in the Iiteraturei.~，刷 、 Therefore、 thiべ i 、 the :?5th l'.I町、 Themean .1日，.ot・these 25 patients was 62 years. In contrast to carcinoma of theε‘allbladder. l~ (7：？ヘ、｝けft 1<、patrerits were men. Associated stones in the bile ductメor』：‘dll】la【ider、.，、It、ll'<'<'llin onl~’‘： lti of the cases. Since the tumor easily obstructs the narrow Iumt'n of the円刈i＜、 ductand t川 hl'sdist＜川、1リlof the gallbladder, the most common clinical fratu1れ of <'Ystic dul't <'nf"l'inomn 山口、 l!Jl]'<'I abdominal pain and a palpable mass. Hydrops or empyema ma1・ 、けml'timc、lt、1It'"" I・川 l'Iand jaundice are less frequently present5J. On cholecystograpll¥". DIぐ I・:!{('I'. or I＂‘rcuta 1山 l!Stranshepatic cholangiography, the gallbladder is seldom 1・i叫lけlized. H1川＼＇（＇、円、 thl'即日＇ 1pt (lf l、and findings are also observed in gallstone disease. 1¥loreover、til'tumor is usually N刊行Il日Ithat it cannot be demonstrated on CT, sonography, or other rndiologi<'a I nι1111inatirn1、Tit川 1glt、an enlarged, nonfunctioning gallbladder with no evidence of an i11川川円lり川ti＜、 duct.slo11<ιma 1・be a clue to suspect carcinoma of the cvstic duct, a correct pn・opnati川、 diagnosisol ＜ドli" d1wl carcinoma has never been made5J. 512 日外宝第54巻第6号（昭和60年11月）（ごonsideringthe location of the cystic duct, cholecystectomy and resection of portions of the hepatic and common bile duct討withregional lymph node dissection should be performed. Ac cording to the report of l¥lANABE and Sucrn爪themean duration of survival for cystic duct carcinoma that met FARRAR's criteria was 20.2 months, which is better than that for carcinoma of the gallbladdcr or the extrahepatic bile ducts. However, the overall prognosis of carcinoma of the cystic duct, includingι，tdvanced cases which do not satisfy FARRAR’s criteria, remains unclear. References 1) De Waele B, Beaurang J, et al: Carcinoma of 句、ticduct leading to obstructive jaundice. Dig Dis Sci 29: 865 867, 1984 2) Farrar DA: Carcinoma of the cystic duct. Br J Surg 39 ：・ 183~185, 1951. 3) :¥lanabe T and Sugie T: Primary carcinoma of the cystic duct. Arch Surg 113: 1202 1204, 1978. 4) Cllontefusco P, Spier N, et al: Another facet of :¥lirizi's syndrome. Arch Surg 118: 1221 1223, 1983. 5) Nishimura A, Nakao K, et al: Carcinoma of the cystic duct: A case report目（inJapanese) Jpn J Castro-enterol 72: 1095-1102, 1975. 61 Pack GT and Teng PK: Carcinoma of cystic duct leading to hydrops of gallbladder. JAMA 203: 175-176, 1968 71 RalJinovitch j句 Arlen:¥I. et al: Primary carcinoma of the cystic duct: Report of two cases. Arch Surg 80: 424-433, 1960. 8) Wada V. Kuroda A, et al: （、arcinomaof the cystic duct. (in Japanese）“Geka Chiryo”50: 375-378, 1984. CARCINOMA OF THE CYSTIC D℃CT 513 和文抄録胆嚢管癌の l例滋賀県立成人病センター外科小切匡史，北村 惰，山田紀彦，野田秀樹浅野元和，吉田昭和胆嚢管癌のl例を経験したので報告する．患者は70歳の男性で， 2年来の右季肋部不快感を主訴として本院を受診した．腹部触診で腫大した胆嚢を触れ， DICでは胆嚢は造影されず， ERCPにて胆嚢管根部Iと相当する部位に淡い陰影欠損を認めた．胆嚢管への結石俵頓による胆’~水腫と考え，開腹術を行ったととろ，結石は存在せず，胆嚢管内lζ1.8×1. 3× 0.6cmの小腫癌を認めた．迅速組織診断にて胆嚢管癌と判明したため，胆嚢摘出術・総肝管総胆管部分切除術・総肝管空腸吻合術を施行した．組織型は中分化型腺癌で，胆道癌取り扱い規約では，（、 cir.胆嚢は水腫型，腫蕩は結節型， SoHinfo HoBoPo N( )M（ー）メt( ) BWo HWo EWo Stage I R1-0Pとなった．術後1年の現在，再発の徴候を認めていなし、胆嚢管癌は稀な疾患であり， Farrarの定義，すなわち①癌の発育が胆嚢管に限局すること，②胆嚢・肝管・総胆管l乙癌を認めないこと，③組織学的に癌と確証される乙と，を満たす症例はさらに少なく，我々の症例が文献上25例自にあたる．胆嚢管癌の症状・所見は，胆石の胆嚢管俵頓の症状・所見とほぼ同一であり，術前l乙胆嚢管癌とみ断された症例は現在まで報告されていないか，依頓結石を画像診断上で証明しえない胆嚢腫大症例では胆嚢管癌の可能性も考慮に入れるべきである．

胆囊管癌の1例

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胆囊管癌の1例

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