Department of Urology, Faculty of Medicine, Kyoto Univeersity
Abstract
1. Fosfomycin was administered to the patients with acute simple cystitis, and its clinical effect was comparatively surveyed with cephalexin as a control drug by means of a double blind study. 2. Fosfomycin was administered to 95 cases (7 dropped out) and cephalexin to 93 cases (7 dropped out). Both were compared as to general effect, antibacterial effect, urinary frequency, burning on urination, urinary pus cells, and change in urinary microorganisms. General effect was observed in 81 out of 83 cases of the fosfomycin group (effectiveness 97.6%) and in 78 out of 83 cases of the cephalexin group (effectiveness 94.0%). There was no significant difference statistically. As to other clinical effects, there was also no statistically significant difference between two groups, but fosfomycin was slightly better than cephalexin as to general effect, antibacterial effect, decrease of bacterial count, colonization and recurrence of cystitis
