Bladder tumors induced by BBN in rats and dogs were useful for the clinical studies of human urinary bladder tumors and experimental chemotherapy. 5-FU, FT-207, CQ, VCR and CDDP were effective as single agents; and, the combination of FT-207 and OK-432, FT-207, ADM and OK-432, and, VCR, BLM and ADM were effective in significantly inhibiting the development of bladder tumors induced by BBN in Wistar rats. In clinical cases, the administration of FT-207, bladder instillation of an anticancer drug, and pre-operative intra-arterial infusion of MMC in addition to bladder instillation were prophylactic for the recurrence of the superficial urinary bladder cancers significantly within one year after operation. ADM, CDDP and radiation were effective regimens for advanced urinary bladder cancers. Multidisciplinary treatment was useful in treating advanced urinary bladder cancers
