Hikasa, Yorinori

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Title Studies on the intravenous administration of fat emulsionprepared by high pressure jetAuthor(s)Hikasa, YorinoriCitationThe Review of Physical Chemistry of Japan (1952), 22(2): 83-83Issue Date1952-12-25URL http://hdl.handle.net/2433/46686RightType Departmental Bulletin PaperTextversionpublisherKyoto UniversityThe Review of Physical Chemistry of Japan Vol. 22 No. 2 (1952)   STUDIES ON THE INTRAVENOUS ADMINISTRATION OF      FAT EMULSION PREPARED BY HIGH PRESSURE JET                               By I'ORIA()RI 1'IIKASAk    At present, a study is being made to a certain degree in relarion to the water contents, carbohydrate, amino acid, vitamine, and also salts as a.remedy for the parenteral nutriment. There is, however, few study concerning the fat, which is the principal source of calorie.    We have conducted this study from 1945. But, in truth, in order to avoid the fatclnboly by intravenous administration f fat emulsion, it is always necessary to make the fat globule smaller than erythrocyte, because the fat globule in the blood or thoracic duct lymph is of the size of 1 ^ -2µ. Therefore, it is ideal for us to inject fat emulsion i  the size of less than 2~ into veins. Accordingly, we have ndeavored to manufacture an emulsion comprising of fat globules ]ess than 2u in diameter. -~~ We had planned and manufactured with our own hands, by the apparatusil s) in the Physico-Chemical L boratory. College of Science (Kyoto University), of producing a fat emulsion by high pressures, with which we had succeeded in manufacturing. a fat emulsion that is fit for intravenous administration, a d could report a pazt of'the experiment for the first time at the 50th ammual meeting of the Japan Surgical Society (1949). And ever since, we are inquiring into the effect of this,emuision i vivo:    Our emulsion_at present contains 15 --20/ cad-liver oil. The rate of composition the said fatty-substance, as shown in Table 1, is mostly neutral fat, containing rape sugar at the rate of 4~ . The size of fat. globules i  less than 2~e and pFI is nearly neutral. Also. it can withstand the disinfection by the application of heat at 100'C; for30 minutes. -The emulsion thus prepared is put in a sterilized vacuum bottle and is being stored-            Table 1 From the result3> "  of our experiments                                      on animals, we assert hat our emulsioncan Neutral fat Fzee fatty acid I Lecithin be fully utilized ven if it iS intravenously    Sss y 7.9 / 6.4 / administered, and it can also be fully utilized                                    from the viewpoint of nutrition, and in thepoint of fat metabolism, we think that we have. clearly demonstrated that the lung is playing an important role. Moreover, in future, we intend to continue the study for exploitation of this emulsion, based on the result of our experiments on animals, in the direction of clinical application.~~ a~ 3) 4Jfrom the 2nd. Surgical Clinic, Kyoto University Hospital (Director: Prof. Dr. Y. Aoyagi) This Journal, Zl, 62 (1901) This Journal, 22, 46 (1902) Jounml aJ the Japanese Su>gica7 Society, b2, Nm 6, 7; 9 (1%1) Jon>nal of Jhe japmrese Smgica! Society,: 53, A'o. 6; 12 (19:12)i

Studies on the intravenous administration of fat emulsion prepared by high pressure jet

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Studies on the intravenous administration of fat emulsion prepared by high pressure jet

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