Bunten, Hannah

Liang, Wei-Jun

Osselton, David M.

Pounder, Derrick

English

Bournemouth University Research Online

A single nucleotide polymorphic mutation in the human mu-opioid receptor severly impairs receptor signalling.

Acute effects of d-amphetamine during the early and late follicular phases of the menstrual cycle in women.

Acute effects of d-amphetamine during the follicular and luteal phases of the menstrual cycle in women.

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

An initial map of insertion and deletion (INDEL) variation in the human genome.

Association analysis of polymorphisms in the mu opioid receptor gene and heroin abuse in Chinese subjects.

Association of a functional ﾵ-opioid receptor allele (C118A) with alcohol dependency.

Association of the mu-opioid recptor gene with smoking cessation.

Bupropion and 4-OHbupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6.

Clarke’s Analysis of Drugs,

Clinical response to morphine in cancer patients and genetic variation in candidate genes.

Could pharmacogenetic data explain part of the interindividual sensitivity to methadoneinduced respiratory depression.

Devine.An initial map of insertion and deletion (INDEL) variation in the human genome.

Does the A118G polymorphism at the µ-opioid receptor gene protect against morphine-6-glucuronide toxicity.

Does the A118G polymorphism at the ﾵ-opioid receptor gene protect against morphine-6-glucuronide toxicity.

Estradiol enhances behavioural sensitization to cocaine and amphetamine-stimulated striatal [3H] dopamine release.

Estrogen rapidly potentiates amphetamine induced striatal dopamine release and rotational behaviour during microdialysis.

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Gender and age influences on human-brain mu-opioid receptor binding measured by PET.

Gender difference in substance use disorders.

Genetic variability and clinical efficacy of morphine.

Genetics of two ﾵ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol and drug dependent subjects.

Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping.

Increased density of mu-opioid receptors in the post-mortem brains of suicide victims.

Linkage disequilibirium and associationJournal of Analytical Toxicology,Vol.

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment.

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behaviour.

Mu opioid receptor gene variants: lack of association with alcohol dependence.

OPRM1 and CYP2B6 gene variants as risk factors in methadone–related deaths.

Pharmacogenomics and its applications.

Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP2D6 serve as an adjunct for certifying methadone toxicity?

Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: genotyping cytochrome P450 2D6 for oxycodone cases.

Sex differences in drug abuse.

Sex differences in the vulnerability to drug abuse: a review of preclinical studies.

Sex- and gender-related differences in the neurobiology of drug abuse.

Single-nucleotide polymorphism in the human mu opioid receptor gene alters ʲ-endorphin binding and activity: possible implications for opiate addiction.

Some gender differences in alcohol and polysubstance users.

Stereoselective block of hERG channel by (s)-methadone and QT interval prolongation in CYP2B6 slow metabolisers.

Stereoselective metabolism of methadone n-demethylation by cytochrome P4502B6 and 2C19.

Substantial attributable risk related to a functional muopioid receptor gene polymorphism in association with heroin addiction in Central Sweden.

The pharmacogenetics research network: from SNP discovery to clinical drug response.

The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor.

Interindividual variability in the prevalence of

OPRM1 and CYP2B6 gene variations may identify

drug-susceptible populations

http://eprints.bournemouth.ac.uk/18477/1/InterindividualVariability_in_the_Prevalence_of.pdf

Interindividual variability in the prevalence of OPRM1 and CYP2B6 gene variations may identify drug-susceptible populations

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