A Widespread ocurrence of an unusual disease of cattle has appeared in Indiana dairy and beef herds. It was characterized clinically by fever, nasal discharge, erosions of the buccal mucosa, lameness, cough and profuse diarrhea and at necropsy by congestion, hemorrhages and erosions of the mucosa of the entire digestive tract and congestion of the upper portion of the respiratory system. The disease was readily transmitted to calves both by direct and indirect contact and by inoculation of filtrates of blood obtained from affected animals. It has been called transmissible erosive gastroenteritis of cattle