Summarizing the evidence of the performance of diagnostic tests for Salmonella spp. in swine: A systematic review approach

Abstract

A systematic review was undertaken in order to identify, critically appraise and synthesize the existing literature on the diagnostic performance (e.g. Se and Sp of the test) and agreement (e.g. kappa and correlation coefficients) of conventional bacterial culture, enzyme-linked immunosorbent assays and polymerase chain reaction assays used to detect and monitor Salmonella spp. in swine. 2110 citations were identified and 160 were relevant to the research objectives. Quality assessment is complete for 150 of these references; 73 were excluded due to estimates of test performance not being clearly reported and insufficient raw data available for post-hoc analysis. Although the review is still in progress, early experiences indicate problems with lack of standardization in the design, conduct and reporting of studies of diagnostic test evaluation in this area. This review will provide valuable information by identifying gaps in existing research and providing direction for future work on the standardization of tests examined in this review