Ac-225-DOTATOC – an empiric dose finding for alpha particle emitter based radionuclide therapy of neuroendocrine tumors

Abstract

There are no established dosimetry tools to predict toxicity of “targeted alpha-therapy” (TAT), yet. We conducted an empiric dose escalation to find the maximum tolerable dose (MTD) of single cycle and fractionation concepts for Ac-225-DOTATOC radionuclide therapy.JRC.E.5-Nuclear chemistr