Azarko, I. I.

Harbatsevich, H. I.

Koval’chuk, T. V.

Loginova, N. V.

Osipovich, N. P.

Petrashevskaya, T. V.

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Bioactive Cu(II) and Zn(II) complexes with Mannich bases 
H. I. Harbatsevich, T. V.Petrashevskaya, T. V.Koval’chuk,  
N. V.Loginova, N. P.Osipovich, I. I Azarko, G. I.Polozov  
Research Institute for Physical Chemical Problems, Belarusian State University, Minsk, Belarus, 
e-mail: hleb.harbatsevich@gmail.com 
Cu(II) and Zn(II) complexes with various organic ligands are known to possess anticonvul-
sant, antiproliferative, anti-inflammatory, antiviral, antiparasitic, and antimicrobial activity. A 
higher antimicrobial effect of the complexes as compared with that of the initial ligands is 
achieved due to their higher lipophilicity resulting from complexation as well as to the influence 
of the metal ions on the cellular structure and processes. To produce effective antimicrobial 
agents, it is necessary to carry out further investigations of Cu(II) and Zn(II) with already known 
and novel ligands and to determine their structural, thermodynamic and pharmacological charac-
teristics. 
The process of complexation of Cu(II) и Zn(II) ions with Mannich bases in water-THF was 
investigated. It was found potentiometrically that complexes with the ratio M : L = 1 : 2, were 
formed, their stability constants were determined (β = 11,78-14,26). The complexes synthesized 
were shown to be neutral, amorphous and thermally stable. Their coordination polyhedra had the 
composition [МN2O2] and square-planar or tetrahedral geometry (Figure). A high antifungal ac-
tivity (RI = 80–100 %) of the metal complexes against moulds Alternaria alternata, Fusarium 
spp., Sclerotinia sclerotiorum was established. 
 
Fig. Structural schemes of the Cu(II) and Zn(II) complexes with the ligands HLI – HLV 
References 
1. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine / Ed. 
by M. Gielen, E. R. T. Tiekink (2005) 598. 
2. N. Raman, V. Muthuraj,  S. Ravichandran  et al.  Proc. Indian Acad. Sci. (Chem. Sci.), (2003) 161. 
 


Bioactive Cu(II) and Zn(II) complexes with Mannich bases

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Bioactive Cu(II) and Zn(II) complexes with Mannich bases

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