Gordon G. Hammes, University Distinguished Service Professor of Biochemistry, Emeritus, Duke University and Professor Emeritus, Chemistry and Chemical Biology, Cornell University, presented a lecture on Tuesday, March 23, 2010, 11 AM in MiRC 102-A on the Georgia Tech Campus.Runtime: 72:10 minutesThe role of conformational changes in enzyme catalysis will be discussed. A model will be advanced consisting of conformational ensembles and multiple reaction pathways to explain the incredible catalytic efficiency of enzymes. The results of ensemble and single-molecule experiments obtained with dihydrofolate reductase will be presented that support this model
