Plate on p. [38] of: Australian picture pleasure book / Walter G. Mason.; Rex Nan Kivell Collection NK2106/99.; U815; S1327

Bech, B H

Halldorsson, T I

Henriksen, T B

Hrolfsdottir, L

Maslova, E

Olsen, S F

Rytter, D

Mason, Walter G.

National Library of Australia Digital Object Repository

View of Mummell, an estate near Goulburn, N.S. Wales [picture] /

To access publisher's full text version of this article click on the hyperlink at the bottom of the pageLimited knowledge exists on the long-term implications of maternal gestational weight gain (GWG) on offspring health. Our objective was to examine whether high GWG in normal weight women is associated with adult offspring cardio-metabolic risk factors.We used a cohort of 308 Danish women who gave birth in 1988-89 and whose offspring participated in a clinical examination at 20 years of age. Main outcome measures were offspring body mass index (BMI), waist circumference, weight-regulating hormones, blood lipids and glucose metabolism. Associations were assessed using multivariable linear and logistic regression models.A weak positive association was observed between GWG during the first 30 weeks and offspring anthropometry. Each 1-kg increase in maternal GWG was associated with 0.1-kg m(-2) higher (95% confidence interval (CI): 0.01, 0.2) offspring BMI and 10% (95% CI: 0.1%, 20%) higher odds of offspring overweight at the age of 20 years, with similar associations observed in both sexes. However, sex differences were observed for the association between maternal GWG and specific cardio-metabolic risk factors. Hence, a 1-kg increase in GWG was associated with 3.4% (95% CI; 0.8, 6.0%) higher homeostasis model assessment-estimated insulin resistance (HOMA-IR), 3.7% (95% CI: 1.4%, 6.2%) higher insulin and 10.7% (95% CI: 5.7%, 15.9%) higher leptin levels in male offspring. These associations were not observed in females, which may partly be explained by more frequent reports of dieting and physical exercise at follow-up among female offspring.In normal-weight women, high GWG may have modest long-term implications on offspring cardio-metabolic risk factors at adult age

Hirsla - Landspítali University Hospital

Gestational weight gain in normal weight women and offspring cardio-metabolic risk factors at 20 years of age.

Landspítali University Hospital Research Archive

International Journal of Obesity

View of Mummell, an estate near Goulburn, N.S. Wales [picture] /

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National Library of Australia Digital Object Repository

Hirsla - Landspítali University Hospital

Landspítali University Hospital Research Archive