Title devised by cataloguer based on other reference sources.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4180779

International Parkinson's Disease Genomics Consortium (IPDGC)

Jonsson, Palmi V

Sveinbjornsdottir, Sigurlaug

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p<5×10(-10), PARK16/1q32, STX1B/16p11, FGF20/8p22, STBD1/4q21, and GPNMB/7p15). Two of these five loci have been suggested by previous association studies (PARK16/1q32, FGF20/8p22), and this study provides further support for these findings. Using a dataset of post-mortem brain samples assayed for gene expression (n = 399) and methylation (n = 292), we identified methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci, hence suggesting potential molecular mechanisms and candidate genes at these risk loci.Wellcome Trust/MRC 	
WT089698 
Department of Health NIHR Biomedical Research Centre 	 
Parkinson's UK 	
8047 
J-0804 
Medical Research Council 	
G0700943 
Wellcome Trust 	
085475/B/08/Z 
085475/Z/08/Z 
Wolfson-Royal Society 	 
UK Medical Research Council 	
G0901254 
Reta Lila Weston Trust for Medical Research 	 
Landspitali University Hospital 	 
Icelandic Research Council 	 
European Community 	
PIAP-GA-2008-230596 MarkMD 
National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services 	
Z01 AG000949-02 
Z01-ES101986 
US Department of Defense 	
W81XWH-09-2-0128 
National Institutes of Health 	
NS057105 
RR024992 
American Parkinson Disease Association (APDA) 	 
Barnes Jewish Hospital Foundation 	 
ForschungszentrumfurUmwelt und Gesundheit (GSF) 	 
German Federal Ministry of Education, Science, Research, and Technology 	 
State of Bavaria 	 
German National Genome Network (NGFNplus) 	
01GS08134 
German Federal Ministry of Education and Research (BMBF) NGFN 	
01GR0468 
Helmholtz Association 	
HA-215 
French National Agency of Research 	
ANR-08-MNP-012 
National Research Funding Agency 	
ANR-08-NEUR-004-0

Hirsla - Landspítali University Hospital

A two-stage meta-analysis identifies several new loci for Parkinson's disease.

Landspítali University Hospital Research Archive

PLoS Genetics

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