Huang, CKY

Luo, XJ

Mao, J

Niu, LN

Pashley, DH

Tay, FRCM

Wang, TD

Yang, HY

Yiu, CKY

Zhang, W

Zhou, LQ

Scientific Reports

PubMed

HKU Scholars Hub

Biomimetic intrafibrillar mineralization of type I collagen with intermediate precursors-loaded mesoporous carriers

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analogstabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.NIDCR [R01 DE015306-06]; National High Technology Research and   Development Program of China [2015AA020942]; NSFC [81400555]SCI(E)PubMedARTICLEmaojing1999@yahoo.com; ftay@gru.edu11199

Zhang, Wei

Luo, Xiao-juan

Niu, Li-na

Yang, Hong-ye

Yiu, Cynthia K. Y.

Wang, Tian-da

Zhou, Li-qun

Mao, Jing

Huang, Cui

Pashley, David H.

Tay, Franklin R.

Institutional Repository of Peking University

Biomimetic Intrafibrillar Mineralization of Type I Collagen with   Intermediate Precursors-loaded Mesoporous Carriers

Biomimetic intrafibrillar mineralization of type I collagen with intermediate precursors-loaded mesoporous carriers

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