Liu, Yingzhao

Lu, Liwei

Ma, Jie

Mao, Chaoming

Peng, Huiyong

Rui, Ke

Tang, Xinyi

Tian, Jie

Wang, Shengjun

Wang, Yungang

Xu, Huaxi

Zhu, Chenlu

International Journal of Molecular Sciences

PubMed

Hashimoto’s thyroiditis (HT) is an organ-specific immune disease characterized by the presence of lymphocytic infiltration and serum autoantibodies. Previous studies  have confirmed the critical role of Th17 cells in the pathopoiesis of HT patients. Additionally, regulatory T cells (Treg) display a dysregulatory function in autoimmune disease. The purpose of this study is to investigate the alteration of Th17 and Treg cells in HT patients and explore contributing factors. We found there was an increased ratio of Th17/Treg in HT patients and a positive correlation with autoantibodies (anti-TgAb).  In addition, there was an increased level of GITRL, which has been demonstrated to be correlated with the increassement of Th17 cells in the serum and thyroid glands of  HT patients; the upregulated serum level of GITRL has a positive correlation with the percentage of Th17 cells in HT patients. In summary, an increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto’s thyroiditis

Yingzhao Liu

Xinyi Tang

Jie Tian

Chenlu Zhu

Huiyong Peng

Ke Rui

Yungang Wang

Chaoming Mao

Jie Ma

Liwei Lu

Huaxi Xu

Shengjun Wang

Multidisciplinary Digital Publishing Institute

Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis

Liu, Y

Tang, X

Tian, J

Zhu, C

Peng, H

Rui, K

Wang, Y

Mao, C

Ma, J

Lu, L

HKU Scholars Hub

Crossref

http://doaj.org/search?source=%7B%22query%22%3A%7B%22bool%22%3A%7B%22must%22%3A%5B%7B%22term%22%3A%7B%22id%22%3A%227eff40410316404e808073288739d593%22%7D%7D%5D%7D%7D%7D

Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis

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Multidisciplinary Digital Publishing Institute

HKU Scholars Hub

Crossref