Poster PresentationInterleukin-17A (IL-17A) has been shown to associate
with a variety of infection diseases. In this study, we
investigate whether IL-17A affects cytokines production
of human peripheral blood-derived macrophages during
Mycobacteriun bovis BCG or Klebsiella pneumoniae
infection. We observed that IL-17A-treated macrophages
exhibited suppressed productions of TNF-α and IL-6 in response to BCG infection. The reduction of cytokines
production was not associated with cell death. On the other
hand, IL-17A promoted TNF-α and IL-6 production by
macrophages during K. pneumoniae infection. Furthermore,
IL-17A did not affect TNF-α production induced by LPS
and Pam3
Cys, which are TLR4 and TLR2 agonists,
respectively. The data suggest that the differential regulation
of cytokines production by IL-17A requires whole
bacterium infection.published_or_final_versio
