Conference Theme: Cell Biomaterial ReactionOpen Access JournalINTRODUCTION: Long segmental diaphyseal bone loss often results from high energy trauma like blast injury, osteomyelitis or wide excision of malignant conditions. Treatment of this long segmental diaphyseal defects remain a difficult clinical problem. In the literature, many authors have reported that bone loss more than 2.5 cm always require bone grafting. This is probably the critical size defect in human. Non-vascularized bone graft frequently fails if the defect is longer than 6-7 cm. 2.5 cm is probably the critical size defect in human and 7 cm is likely the critical size for non-vascularized bone graft. Various treatment methods are adopted currently to address this problem, including vascularized bone graft, distraction osteogenesis and massive allograft. However, all these methods are associated with …published_or_final_versio
