Oral PresentationINTRODUCTION: Mdm2, an E3 ubiquitin ligase, regulates the tumour suppressor p53 by enhancing its proteasomemediated degradation through the protein-protein interaction. A small molecule Nutlin-3a has been shown to disrupt the interaction between p53 and MDM2, thereby up-regulating expression of p53 in cancer cells. Therefore, this small molecular represents a promising therapeutic agent for cancer. However, the effect of nutlin-3a on glucose homeostasis has never been explored so far. In this study, we aimed to investigate whether nutlin-3a affects glucose metabolism using both in-…published_or_final_versio
