BACKGROUND AND AIMS: Metabolic syndrome (MS) comprises a constellation of metabolic abnormalities associated with a high risk of developing diabetes and cardiovascular diseases. Central obesity, with related insulin resistance and inflammation are considered the core of the underlying pathogenesis of MS. Fibrinogen, an acute-phase reactant in the coagulation cascade, has been shown to play pivotal role in determining the extent of local or systemic inflammation. In this study, we examined whether plasma fibrinogen was predictive of incident MS in a community-based Chinese cohort. MATERIALS AND METHODS: Subjects were recruited from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort. 2780 subjects were recruited in 1995-6 with baseline assessment performed. 1416 subjects without MS at …postprin
