Poster Session 2: Host-Cell Interactions – Non-Coding RNA, Exosomes, and Epigenetics: no. 13.19MicroRNAs (miRNAs) play a critical role in post-transcriptional regulation of gene expression. Several herpesviruses have been shown to express viral miRNAs. Identification of the targets of these miRNAs might derive mechanistic insight into viral pathogenesis. We have previously demonstrated that Epstein-Barr virus (EBV)-encoded miR-BART5 targets p53-upregulated modulator of apoptosis (PUMA) in nasopharyngeal carcinoma (NPC) and this regulation is important for the EBV persistence and survival of EBV-infected cell survivals. In addition to the anti-apoptotic role of miR-BART5, other oncogenic activities of EBV miRNAs may also contribute to the development of lymphocytic or epithelial malignancies. In this study, we screened for potential targets of EBV miRNAs and found that EBV miR-BART3-5p potently suppressed the expression of DICE1 tumor suppressor in cultured cells. DICE1 is known …postprin
