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Effects of functional transient receptor potential channels on proliferation and migration in human cardiac c-kit+ cells

Abstract

Poster PresentationINTRODUCTION: Human adult c-kit+ cardiac stem cell are characterised by the expression of c-kit in the absence of lineage markers such as Nkx2.5. They are self-renewing, clonogenic and multipotent, giving rise to a minimum of three differentiated cell types: myocytes, smooth muscle, and endothelial vascular cells. These cells, although not specifically programmed for myocardial differentiation, have been shown to improve cardiac function in a myocardial injury/reconstitution assay. However, cell biology is not fully understood. The present study was to investigate the expression of transient receptor potential (TRP) channels in hum…published_or_final_versio

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