DMM 2011 entitled: Re-engineering Regenerative MedicinePoster Session - Tissue Engineering: no. 82Type I collagen has been widely used as scaffold for tissue engineering because of its excellent biocompatibility and negligible immunogenicity. We previously have developed a collagen microencapsulation technology entrapping many cells including human mesenchymal stem cells (hMSCs) in microspheres made of nanofibrous collagen meshwork. Nevertheless, little is understood about how stem cells interact with and remodel the collagen meshwork. This study aims to investigate collagen remodeling by human mesenchymal stem cells (hMSCs) in terms of degradation, new matrix synthesis, and re‐organization. We …postprin
