Genomics approach to identify drug transporter ABCF1 associated with liver cancer recurrence and chemo-resistance

Abstract

Poster Session 33 - New Models, Screens, and Diagnostics for Target Identification: abstract no. 882BACKGROUND: Liver cancer is the third leading cause of cancer death globally. Surgery is the mainstay for early stage patients with the best survival outcome, but cancer recurrence is still common after curative surgery. Chemotherapy has been widely used to treat advanced liver cancer but with marginal efficacy. There is an urgent need to elucidate the key genes that regulate recurrence and chemo-resistance in the clinical situation. Recently, we have demonstrated that the novel growth factor granulin-epithelin precursor (GEP) is associated with chemo-resistance and recurrence-free survival. GEP has been identified as a potential therapeutic target for liver cancer in our ...link_to_OA_fulltextThe Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012