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Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese
Authors
L Baum
ACF Hui
+7 more
P Kwan
CH Lui
PW Ng
NC Sin
LKS Wong
V Wong
E Yu
Publication date
1 January 2007
Publisher
'Elsevier BV'
Doi
Cite
Abstract
There is accumulating evidence to suggest that overexpression of efflux drug transporters at the blood-brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure foci, contributes to drug resistance in epilepsy. P-glycoprotein, encoded by the ABCB1 gene, is the most studied drug transporter. There are conflicting data as to whether the CC genotype of the ABCB1 3435C > T polymorphism is associated with drug resistance in Caucasian patients with epilepsy. We investigated this association in ethnic Chinese. ABCB1 3435C > T was genotyped in 746 Han Chinese patients with epilepsy and 179 controls. Patients with drug-resistant epilepsy were more likely to have the TT genotype compared with those with drug-responsive epilepsy (16.7% vs 7.4%, odds ratio = 2.5, 95% confidence interval = 1.4-4.6, P = 0.0009). Our results contrast with those of studies of Caucasians, and highlight the complexity of the possible role of this polymorphism in AED response in different ethnic populations. © 2007 Elsevier Inc. All rights reserved.link_to_subscribed_fulltex
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Last time updated on 01/06/2016