Evaluation quality of life in patients with oral squamous cell carcinoma using UW-QOL

Abstract

目的：应用UW-QOL 第4 版评价口腔鳞癌患者的生存质量(quality of life, QOL)。方法：采用直接翻译并经过适当修改的UW-QOL 第4 版，对97 例确诊为口腔鳞癌的连续患者的术前QOL 进行测量，术后3 个月对其中55 例患者的QOL 作重复测量。采用SPSS12.0 软件包分析量表的信度、效度和反应度。结果：量表总的克朗巴赫系数和分半信度分别为0.725 和0.701；12 个条目可提取4 个因子，累计方差贡献率为65.4%；以SF-36 中文版和FACT-H&N 的头颈特异性子量表FACT-HN 为效标，其效标效度分别为0.543 和0.738；量表能敏感地区分已知的2 组口腔癌患者术前QOL 的差异及口腔癌患者QOL 随时间的变化。结论：UW-QOL 第4 版具有良好的信度和反应度，其测定结构呈多维性，可用于中国人口腔癌患者生存质量的测量。 PURPOSE: To evaluate the quality of life in patients with oral squamous cell carcinoma using UW-QOL version 4. METHODS: The quality of life(QOL) of 97 consecutive patients who were diagnosed as oral squamous cell carcinoma was assessed preoperatively with UW-QOL version 4 which was translated directly and modified necessarily. QOL of 55 patients was examined 3 months postoperatively. The validity, reliability and responsiveness of the scale were analyzed using SPSS12.0 software package. Statistical methods involved in this study included Mann-Whitney U test, Wilcoxon test, factor analysis, reliability analysis, and bivariate correlation analysis. RESULTS: The internal consistency α of the instrument was 0.725, and the split-half reliability was 0.701. An exploratory factor analysis on the 12 items produced 4 factors, and the analysis explained 65.4% of the total variation. The criterion validity with SF-36 and FACTHN was 0.543 and 0.738, respectively. The instrument could detect the differences of preoperative QOL between T1+T2 group and T3+T4 group and the changes of QOL over time sensitively. CONCLUSION: The UW-QOL version 4 could measure the quality of life in oral cancer patients with good reliability, responsiveness and multi-dimensional constructs, it can be used in Chinese population with oral cancer