CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma
Authors
KW Chan
LC Cheung
+9 more
Y Chung
MKC Hui
KKY Lai
S Law
NP Lee
JM Luk
G Srivastava
JC Tang
SW Tsao
Publication date
1 January 2012
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer. RON is a transmembrane receptor overexpressed in various cancers; however, the clinical significance of its phosphorylated form (pRON) is not fully deciphered. This report is the first to investigate the expression and clinical significance of pRON in human ESCC. Quantitative polymerase chain reaction revealed an up-regulation of RON mRNA in 70% (7/10) of ESCC tissues when compared to the adjacent nontumor tissues. An overexpression of pRON protein was found in most of the ESCC cell lines studied (4/5) when compared to two non-neoplastic esophageal epithelial cells using immunoblot. In 64 ESCC tissues, pRON was localized at the cell membrane, cytoplasm and nucleus in 15 (23.4%), 63 (98.4%) and 61 (95.3%) cases using immunohistochemistry. Patients having high expression of cytoplasmic pRON significantly associated with shorter median survival when compared to those with low expression (25.41 months vs. 14.43 months), suggesting cytoplasmic pRON as a potential marker for poor prognosis in ESCC patients. © 2011 Springer Science+Business Media, LLC.link_to_subscribed_fulltex
Similar works
Full text
Available Versions
The Hong Kong Polytechnic University Pao Yue-kong Library
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ira.lib.polyu.edu.hk:10397...
Last time updated on 10/02/2018
HKU Scholars Hub
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:hub.hku.hk:10722/144513
Last time updated on 01/06/2016