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research
A hierarchical frailty model applied to two-generation melanoma data
Authors
Ø Borgan
HK Gjessing
+3 more
M Haugen
TA Moger
BHK Yip
Publication date
1 January 2010
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
We present a hierarchical frailty model based on distributions derived from non-negative Lévy processes. The model may be applied to data with several levels of dependence, such as family data or other general clusters, and is an alternative to additive frailty models. We present several parametric examples of the model, and properties such as expected values, variance and covariance. The model is applied to a case-cohort sample of age at onset for melanoma from the Swedish Multi-Generation Register, organized in nuclear families of parents and one or two children. We compare the genetic component of the total frailty variance to the common environmental term, and estimate the effect of birth cohort and gender. © 2010 The Author(s).published_or_final_versionSpringer Open Choice, 21 Feb 201
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NORA - Norwegian Open Research Archives
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oai:bora.uib.no:1956/4539
Last time updated on 19/04/2016
University of Bergen
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oai:bora.uib.no:1956/4539
Last time updated on 28/10/2021
HKU Scholars Hub
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oai:hub.hku.hk:10722/145073
Last time updated on 01/06/2016