Free Paper Session - Biomedicine: abstract no. A2

Chan, DW

Fung, FKC

Liu, VWS

Ngan, HYS

The 22nd Lorne Cancer Conference, Lorne, Victoria, Australia, 11-13 February 2010

HKU Scholars Hub

PITX2 transcription factor is overexpressed and involved in the tumorigenicity of ovarian cancer

136 T H  A N N U A L  M E E T I N GC E N T R E  F O R  C A N C E R  R E S E A R CHScientific Programme|  November 4, 2009  |November 4, 2009 (Wednesday)1:00 pm RegistrationSeminar Room 3 Seminar Room 1-2Free Paper Session – Psychosocial OncologyChairperson: HCY Chan, Society for the Promotion of Hospice Care, Hong KongFree Paper Session – BiomedicineChairperson: GSW Tsao, The University of Hong Kong, Hong KongAbstract no. Abstract no.2:00 pmA65Let the Dying Shine: Are they Lessons of Dying or Lessons of Living?Meaning Making of Patients with Terminal Cancer in Chinese Cultural ContextPOK Ng, PPY Leung, CLW Chan and JYM LuiA9The Forkhead Transcription Factor FOXO3a Increases Akt Activity in Breast Cancer Cell Lines Through a Feed-back MechanismJ Chen, KYK Chan, LH Wu, YC Ip, EWF Lam andUS Khoo2:10 pmA61Seeking Immortality: Helping Hospice Patients Define Their LegacyL Kcomt and RJ Zalenski A2Involvement of Nucleophosmin in Transcriptional Activation of PCNA in Cellular Response to UVYM Chiu, JJ Wung, CP Chuang and BYM Yung2:20 pmA63Strategies Used by Children to Cope with the Diagnosis and Treatment of Cancer: An Exploratory StudyWHC LiA6Robust Dose-Finding Method in Phase I Oncology Clinical TrialsG Yin, Y Yuan and X Lei2:30 pmA68The Final Stage of Living: Negotiating the Crisis of DeathR Zalenski and R Raspa A22PITX2 Transcription Factor is Overexpressed and Involved in the Tumorigenicity of Ovarian CancerFKC Fung, DW Chan, VWS Liu and HYS Ngan2:40 pm Coffee BreakYoung Investigator Award – Psychosocial OncologyChairperson: HCY Chan, Society for the Promotion of Hospice Care, Hong KongAdjudicators: S Hickman, University of California, USASMC Pang, The Hong Kong Polytechnic University, Hong KongYoung Investigator Award – BiomedicineChairperson: M Lung, The University of Hong Kong, Hong KongAdjudicators: PW Laird, University of Southern California, USAJCS Chim, The University of HongKong, Hong KongAbstract no. Abstract no.3:10 pmA62Psychosocial and Physical Outcomes after Surgery for Breast Cancer: A Five to Six Year Follow-upYT Kwok, EYY Ho, WWT Lam and R FieldingA38The Role of Proline Rich Tyrosine Kinase 2(Pyk2) on Cisplatin Resistance in HCCW Geng, KT Ng, WL Yau, XB Liu, RT Poon, K Man and ST Fan3:20 pmA74Higher Education and Younger Age are Associated with Better Understanding of Clinical Trials Among Hong Kong Cancer PatientsJ Tsang, TTS Lau, VKH Lee, ST Yung, VWK Li, TK Cheung, WWT Lam, VHF Lee, GKH Au, DLW Kwong and DTT ChuaA55Functional Studies of a Cell Cycle and Angiogenesis-related Candidate Tumor Suppressor Gene, Mirror Image Polydactyly1, in Nasopharyngeal CarcinomaAKL Cheung, HL Lung, JMY Ko, Y Cheng, EJ Stanbridge, ER Zabarovsky, JM Nicholls, D Chua, GSW Tsao, XY Guan and ML Lung3:30 pmA66Patient and Companion Participation in Breast Cancer Consultations: What do they want to know?TWT Wong, WWT Lam, Y Lo, C Fabrizio, M Chan, A Or and R FieldingA31Impact of Antiviral Therapy on the SurvivalOutcome of Patients after Major Hepatectomy for Hepatitis B-related Hepatocellular CarcinomaACY Chan, KSH Chok, WK Yuen, KKC Ng, RTP Poon, CM Lo and ST Fan14 1 6 T H  H O N G  KO N GI N T E R N A T I O N A L  C A N C E R  CO N G R E S SNovember 4, 2009 (Wednesday)Abstract no. Abstract no.3:40 pmA67Motivational Styles and its Effects on the Subjective Well-being and Coping Efficacy of People with Terminal-cancer and their Surviving SpousesYMY Yuen, AHY Ho, CLW Chan, SF Lam, AYM Chow and RKY LiuA15Compartment-specific MicroRNA Expression Profiles in Colorectal CancerJKY Lau, HHN Yan, ST Yuen, ASY Chan, WL Law, SY Leung and TL Chan3:50 pmA60Development and Evaluation of a Decision Aid Booklet for Chinese Women Facing a Choice of Breast Cancer SurgeryAHY Au, WWT Lam, M Chan, A Or, A Kwong, D Suen, AL Wong, PN Butow and R FieldingA29Enhancer of Zeste Homolog 2 (EZH2) wasInvolved in Hepatocellular Carcinoma (HCC) Progression Through Gene SilencingSLK Au, CM Wong and IOL Ng4:00 pm Deliberation by adjudicators on YIA.A43CD133+ Liver Cancer Stem Cells PromoteTumor Growth and Angiogenesis ThroughIncreased Interleukin-8 SecretionKH Tang, S Ma, XY Guan and KW Chan4:10 pmA73The Association of Low to Moderately High-levels of Ionizing Radiation Exposure and the Development of Soft Tissue SarcomasD Samartzis, N Nishi, J Cologne, M Hayashi, K Kodama, EF Miles, S Funamoto, A Suyama, M Soda and F Kasagi4:20 pmA36Characterize the Role of Granulin-epithelinPrecursor in Fetal Liver Development andHepatocellular CarcinomaPF Cheung and ST Cheung4:30 pmA12Novel de novo BRCA1 Mutation in a Chinese Woman with Early Onset Breast CancerEYH Tang, EKO Ng, CLP Wong, FBF Law, MT Cheung, MY To, ESK Ma, DW West, JM Ford and A Kwong4:40 pmA42Actopaxin: A Novel Regulator of Cell Migration and Invasion in Human Hepatocellular CarcinomaL Ng, RTP Poon, BCY Wong and RWC Pang5:00 pm Deliberation by adjudicators on YIA.Scientific Programme  November 4, 2009  Continued156 T H  A N N U A L  M E E T I N GC E N T R E  F O R  C A N C E R  R E S E A R CHScientific Programme|  November 5, 2009  |November 5, 2009 (Thursday)Lecture Theatre 39:15 am Opening Ceremony Welcoming address by Professor George Tsao, Director, Centre for Cancer Research,    Li Ka Shing Faculty of Medicine, HKU Officiating address by Professor SP Lee, Dean, Li Ka Shing Faculty of Medicine, HKU Presentation of Young Investigator Award by Professor SP Lee Group Photo9:30 am HKICC LectureChairperson: G Chan, The University of Hong Kong, Hong KongThe Allogeneic Graft as an Immunotherapeutic Tool for the Treatment of CancerR Handgretinger, University of Tübingen, Germany10:30 amCoffee Break(sponsored by Novartis Pharmaceuticals (HK) Limited)Lecture Theatre 3 Lecture Theatre 411:00 am -1:00 pmState-of-the-Art LectureTumour ImmunologyChairperson: IOL Ng, The University of Hong Kong, Hong KongState-of-the-Art LecturePsychosocial Oncology (HKCF)Chairperson: A Yan, CancerLink Support Centre(Wong Tai Sin)11:00 amMolecular and Functional Conditioning of Dendritic Cells for DC-based Immunotherapy against Tumours – Guiding the “Misguided”FP Huang, Imperial College London, UK11:00 amTwo Wings of a Great Bird: Research on Mindfulness and Compassion for Our Patients and OurselvesS Hickman, University of California, USASymposiumTumour and Stroma InteractionChairperson: GSW Tsao, The University of Hong Kong, Hong KongSymposiumPsychosocial Oncology (HKCF)Chairperson: A Yan, CancerLink Support Centre(Wong Tai Sin)12:00 noonFGFR2-positive Fibroblasts Provide a Suitable Microenvironment for Tumor Development and Progression in Oesophageal CarcinomaXY Guan, The University of Hong Kong, Hong Kong12:00 noonNasopharyngeal Cancer – Unique ChallengesAWM Lee, Pamela Youde Nethersole Eastern Hospital, Hong Kong12:30 pmAkt1 (Protein Kinase Bα) in Tumor Growth and AngiogenesisJ Chen, Legacy Clinical Research and Technology Centre, USA1:00 pm Lunch16 1 6 T H  H O N G  KO N GI N T E R N A T I O N A L  C A N C E R  CO N G R E S SNovember 5, 2009 (Thursday)Lecture Theatre 3 Lecture Theatre 4 Seminar Room 1-22:00 pm -3:30 pmSymposiumMolecular ImagingChairpersons: PL Khong and K Man, The University of Hong Kong, Hong KongState-of-the-Art LectureFamily Physicians’ Role in CancerChairperson: J Liang, Hong KongCollege of Family Physicians, Hong KongWorkshopPsychosocial Oncology (HKCF)Chairperson: V Cheng, CancerLink Support Centre (Wong Tai Sin)2:00 pmDiffusion-weighted MR-imaging in Oncology: Old Technique, New FrontiersDM Koh, Royal Marsden Hospital, UK2:40 pmOptical Molecular Imaging in Anti-Cancer Drug DiscoveryGJ Zhang, Shantou University, China3:00 pmPET-CT in Malignant Lymphoma: Updates and Local ExperiencePL Khong, The University of HongKong, Hong Kong3:20 pmQ&A Session2:00 pmNew Paradigms in Cancer Prevention, Diagnostics and Therapeutics in Family PracticeJ Emery, University of Western Australia, Australia3:00 pmQ&A Session2:00 pm“Where Are My Feet?”:Implementing a Brief Mindfulness – Based Intervention for Anticipatory Anxiety in an Oncology SettingS Hickman, University of California, USA3:30 pmCoffee Break(sponsored by Novartis Pharmaceuticals (HK) Limited)4:00 pm -5:30 pmState-of-the-Art LectureGynaecological CancerChairperson: HYS Ngan, The University of Hong Kong, Hong KongSymposiumPublic Health Perspectives in Cancer Prevention and ControlChairperson: WWT Lam, The University of Hong Kong, Hong KongWorkshopPsychosocial Oncology (HKCF)Chairperson: V Cheng, CancerLink Support Centre (Wong Tai Sin)4:00 pmRecent Advances in the Chemotherapy Treatment of Ovarian CancerS Wilailak, Mahidol University,Thailand4:00 pmTo Drink (a Carcinogen) or Not to Drink: This is a Major Public Health ChallengeTH Lam, The University of Hong Kong, Hong Kong4:00 pmAccess Inner Resources Through PlayALH Chan, US Registered Drama Therapist, Hong KongSymposiumGynaecological CancerChairperson: HYS Ngan, The University of Hong Kong, Hong Kong4:30 pmCancer and Genetics - From a Public Health PerspectiveDKM Ip, The University of Hong Kong, Hong Kong4:45 pmOvarian Cancer Screening - An UpdateKF Tam, Queen Mary Hospital, Hong Kong5:05 pmPathology of Ovarian Carcinoma:New Insights on Origin and PathogenesisA Cheung, The University of Hong Kong, Hong Kong5:25 pmQ&A Session5:00 pmCost Effectiveness of Mammography ScreeningIOL Wong, The University of Hong Kong, Hong KongScientific Programme  November 5, 2009  Continued176 T H  A N N U A L  M E E T I N GC E N T R E  F O R  C A N C E R  R E S E A R CHScientific Programme|  November 6, 2009  |November 6, 2009 (Friday)Lecture Theatre 39:10 am CCR LectureChairperson: SY Leung, The University of Hong Kong, Hong KongOrigins and Clinical Applications of Cancer EpigenomicsPW Laird, University of Southern California, USA10:10 am Coffee BreakLecture Theatre 3 Lecture Theatre 410:30 am -12:30 pmSymposiumDNA Damage and MutationChairperson: GSW Tsao, The University of Hong Kong, Hong KongState-of-the-Art LecturePsychosocial Oncology (SPHC)Chairperson: CLW Chan, The University of Hong Kong, Hong Kong10:30 amRegulatory Ubiquitylation in the DNA Damage ResponseMSY Huen, The University of Hong Kong, Hong Kong11:05 amThyroid Transcription Factor-1 (TTF-1) Mutation in Multinodular Goitre and Papillary Thyroid Carcinoma PatientsE Ngan, The University of Hong Kong, Hong Kong10:30 amDignity and the Landscape of Distress in Palliative CareHM Chochinov, University of Manitoba, CanadaState-of-the-Art LectureGenetic PredispositionChairperson: M Lung, The University of Hong Kong, Hong Kong11:40 amGenetic Polymorphisms of Alcohol-metabolizing Enzymes and Oesophageal Squamous Cell Carcinoma in East Asian DrinkersA Yokoyama, National Hospital Organization Kurihama Alcoholism Centre, Japan12:30 pm Lunch18 1 6 T H  H O N G  KO N GI N T E R N A T I O N A L  C A N C E R  CO N G R E S SNovember 6, 2009 (Friday)Lecture Theatre 3 Lecture Theatre 4 Lecture Theatre 21:30 pm -3:30 pm /3:45 pmSymposiumOesophageal CancerChairperson: M Lung,The University of Hong Kong, Hong KongEducational SymposiumNursing Perspectives in Cancer Prevention and ManagementChairpersons:SSC Chan, The University of Hong Kong, Hong KongSY Chiu, Queen Mary Hospital, Hong KongSymposiumPsychosocial Oncology(SPHC)Chairperson: T Wong, The Hong Kong Polytechnic University, Hong Kong1:30 pmEvolution in the Management of Oesophageal CancerS Law, The University of HongKong, Hong Kong2:00 pmOncogenes in Oesophageal Squamous Cell CarcinomaJCO Tang, The Hong KongPolytechnic University, Hong Kong1:30 pmOpening address by SSC Chan1:35 pmPublic Health Approach for Cancer Prevention: The Government’s RoleTH Leung, Department of Health of HKSAR, Hong Kong2:00 pmThe ABCD’s of Dignity Conserving CareHM Chochinov, University of Manitoba, Canada2:20 pmA Patient Who Desires on DieMMK Sham, Grantham Hospital, Hong KongSymposiumLiver CancerChairperson: IOL Ng,The University of Hong Kong, Hong Kong1:58 pmCancer Screening: Early Detection and Prevention GuidelinesACH Ying, The Hong KongAnti-Cancer Society, Hong Kong2:40 pmThe Story of a Strong-willed Beautiful LadyA Thorsen, Haven of Hope Hospital, Hong Kong2:30 pmMolecular Pathology of Hepatocellular Carcinoma: Insights of Caveolin-1 in Cancer MetastasisJWP Yam, The University of HongKong, Hong Kong2:45 pmRisk Estimation for Hepatocellular Carcinoma (HCC) in Chronic Hepatitis B PatientsCL Lai, The University of HongKong, Hong Kong3:15 pm - 3:45 pmAn Update on the Surgical Management of Hepatocellular CarcinomaKKC Ng, Queen Mary Hospital, Hong Kong2:21 pmPreventing Cancer Deaths: Nursing Initiatives in Smoking Cessation in Hong KongSSC Chan, The University of HongKong, Hong Kong2:44 pmNursing Management of Cancerous WoundMWK Lee, Queen Mary Hospital, Hong Kong3:07 pmNursing Challenges in Advanced Breast Cancer TherapySSS Mak, Prince of Wales Hospital, Hong Kong3:00 pmQ&A Session3:30 pm Coffee BreakScientific Programme  November 6, 2009  Continued196 T H  A N N U A L  M E E T I N GC E N T R E  F O R  C A N C E R  R E S E A R CHScientific Programme  November 6, 2009  ContinuedNovember 6, 2009 (Friday)Lecture Theatre 3 Lecture Theatre 4 Lecture Theatre 2 Seminar Room 1-2 Seminar Room 34:00 pm -5:40 pmSymposiumTargeted TherapyChairperson: JCS Chim, The University of Hong Kong, Hong KongEducational SymposiumMolecular Biology of CancerChairperson: MP Wong, The University of Hong Kong, Hong KongWorkshop 1Psychosocial Oncology (SPHC)Chairperson:KF Kwan, Society for the Promotion of Hospice Care, Hong KongWorkshop 2Psychosocial Oncology (SPHC)Chairperson: C Li, The Hong Kong Anti-Cancer Society, Hong KongWorkshop 3Psychosocial Oncology (SPHC)Meeting Patient/Family Needs in the Final Stage of LifeChairperson: JST Sham, The University of Hong Kong, Hong Kong4:00 pmCucurbitacin B: An Anticancer DrugHP Koeffler,Cedars-Sinai Medical Centre, USA4:50 pmTargeted and Novel Treatments for Non-small Cell Lung CancerJCM Ho,The University of Hong Kong, Hong Kong5:15 pmTargeted Therapy in Breast CancerJWH Tsang,The University of Hong Kong, Hong Kong4:00 pmDietary Antioxidants for Cancer Prevention: Progress and PromiseTKW Lee,The University of Hong Kong, Hong Kong4:30 pmMitosis and Therapeutic Targets in CancerCWY Man,The Hong Kong Polytechnic University, Hong Kong5:00 pmEpigenetics in Human Acute Leukaemias: a Novel Strategy in Diagnosis and TherapyRK Ng,The University of Hong Kong, Hong Kong4:00 pmStrategies in Engaging Patients and Families in Advance Care PlanningFMY Chan andCCY Cheng,Society for the Promotion of Hospice Care, Hong Kong4:00 pmCoping with Compassion FatigueVKY Lai,Private Practice,Hong Kong4:00 pmThe Goals of the Final Stage of LifeR Raspa,Wayne state University, USA4:30 pmInterventions to Achieve Improved Outcomes During Life’s Final StageR Zalenski,Wayne State University, USA5:00 pmMeasuring Outcomes Toward Fulfilling Goals of Life’s Final Stage of DevelopmentR Zalenski,Wayne State University, USA

http://www.hkicc.org/download/16th%20HKICC%20Scientific%20Programme%20(2009).pdf

PITX2 transcription factor is overexpressed and involved in the tumorigenicity of ovarian cancer

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